CPI-455 HCl

CPI-455 HCl is an inhibitor of KDM5. It can elevate global levels of H3K4 trimethylation (H3K4me3) and decrease the number of DTPs in multiple cancer cell line models.

CAS号

2095432-28-1

分子式

C16H15ClN4O

主要靶点

Histone Demethylase

仅限科研使用

Cat No : CM04524

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Synonyms



产品信息

CPI-455 Hydrochloride is the hydrochloride form of CPI-455. CPI-455 is a specific KDM5 inhibitor with IC50 value of 10nM for inhibition of full-length KDM5A in enzymatic assays. CPI-455-mediated KDM5 inhibition resulted in a dose-dependent increase in global H3K4me3 in HeLa cells. Also it induced a time-dependent increase in H3K4me3 that was detected only after 2 or more days of treatment. The elevation of H3K4 trimethylation mediated by this inhibition of KDM5 by CPI-455 decreased the number of drug-tolerant state in multiple cancer cell line models treated with standard chemotherapy or targeted agents.

CAS号 2095432-28-1
分子式 C16H15ClN4O
主要靶点 Histone Demethylase
主要通路 Epigenetics
分子量 314.7695
MDL NO
Pubchem ID 129896721.0
纯度 98.49%, 此纯度可做参考,具体纯度与批次有关系,可咨询客服
储存条件
粉末 -20°C 3年
液体 -80°C 1年
运输条件 Shipped in cold pack
别名

靶点

TargetActivity
KDM5AIC50=10nM

溶解度

DMSO100 mg/mL
Waterinsoluble

动物研究

剂量Mice: 50 mg/kg, 70 mg/kg[2] (i.p.)
给药途径i.p.

动物实验配方

AdministrationFormulationSolubilityStatus
IP2% DMSO+water2 mg/mLclear
PO0.5% CMC-Na45 mg/mLsuspension

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2