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CP-31398 dihydrochloride

CP-31398 dihydrochloride 是一种 p53 稳定剂，可稳定 p53 的活性构象并促进具有突变型或野生型 p53 的癌细胞系中的 p53 活性。

CAS号

1217195-61-3

分子式

C22H28Cl2N4O

主要靶点

p53

仅限科研使用

Cat No : CM05706

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Synonyms

CP 31398 dihydrochloride

验证数据展示

  • CAS No.: 1217195-61-3

    CP-31398 dihydrochloride
    CAS#: 1217195-61-3

产品信息

CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

CAS号 1217195-61-3
分子式 C22H28Cl2N4O
主要靶点 p53
主要通路 凋亡
分子量 435.4
纯度 99.53%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 CP 31398 dihydrochloride

体外活性

CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells[1]. CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells[2].

溶解度

DMSO:6 mg/ml (13.78 mM)

参考文献

1.Rishu Takimoto, et al. The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis of Human Cancer Cells and Can Stabilize Wild-Type p53 Protein. Cancer Biol Ther. Jan-Feb 2002;1(1):47-55.
2.B A Foster, et al. Pharmacological rescue of mutant p53 conformation and function. Science. 1999 Dec 24;286(5449):2507-10.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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