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CCR6 inhibitor 1

CAS号

2437547-04-9

分子式

C24H23F3N4O3S

主要靶点

CCR

仅限科研使用

Cat No : CM09391

Print datasheet

Synonyms

Human CCR6|Human CCR7|CCR6|CCR7|CCR6 inhibitor 1|CCR-6 inhibitor 1|Moneky CCR6

验证数据展示

  • CAS No.: 2437547-04-9

    CCR6 inhibitor 1
    CAS#: 2437547-04-9

产品信息

CAS号 2437547-04-9
分子式 C24H23F3N4O3S
主要靶点 CCR
主要通路 免疫与炎症|G 蛋白偶联受体|微生物学
分子量 504.52
纯度 98.91%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Human CCR6|Human CCR7|CCR6|CCR7|CCR6 inhibitor 1|CCR-6 inhibitor 1|Moneky CCR6

靶点活性

CCR6 (monkey):0.45 nM|CCR7 (human):9400 nM|CCR6 (human):6 nM

体外活性

在人类CCR6转染的CHO细胞中，CCR6 inhibitor 1 显示出Gi信号抑制活性与细胞迁移抑制活性之间良好的相关性，能够有效抑制依赖CCR6的细胞迁移以及人类初代细胞中ERK磷酸化的增加[1]。

溶解度

DMSO:112.5 mg/mL (222.98 mM)

参考文献

1.Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3067-3072.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2