CCAR1 Recombinant antibody, PBS Only (Capture)

CCAR1 Uni-rAbTM Recombinant Antibody for Cytometric bead array, Indirect ELISA
Cat No. 83936-1-PBS

产品说明书

CloneNo. 240980E11

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

Cytometric bead array, Indirect ELISA

CARP 1, CARP1, CARP-1, Death inducer with SAP domain, DIS

缓冲液配方:  PBS Only
PBS Only
偶联物:  Unconjugated
规格价格库存


Planning an IHC experiment? We recommend our IHCeasy CCAR1 Ready-To-Use IHC Kit. CCAR1 primary antibody included.

产品信息

83936-1-PBS targets CCAR1 as part of a matched antibody pair:

MP00915-2: 83936-1-PBS capture and 83936-2-PBS detection (validated in Cytometric bead array)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human
免疫原 CCAR1 fusion protein Ag18786 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 cell division cycle and apoptosis regulator 1
别名 CARP 1, CARP1, CARP-1, Death inducer with SAP domain, DIS
计算分子量 1150 aa, 133 kDa
GenBank蛋白编号BC132725
基因名称 CCAR1
Gene ID (NCBI) 55749
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ8IX12
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Cell cycle and apoptosis regulator 1 (CCAR1) was originally identified from a functional screening and implicated in retinoid-induced cell cycle arrest and apoptosis. It has been shown that, in breast cancer cells, CCAR1 regulates apoptosis induced by various agents, including chemotherapeutics adriamycin, etoposide, and EGFR inhibitor. It is also involved in mediating anchorage-independent growth of colon carcinoma cells. In addition, CCAR1 plays the role as a co-activator of nuclear receptors to recruit mediator complex. It was found to associate with components of the Mediator and p160 coactivator complexes and is recruited to endogenous NR target genes. CCAR1 is also a binding partner of b-catenin and assists b-catenin in transcriptional activation of Wnt target genes.

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