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C-DIM12

C-DIM12是一种人工合成的Nurr1激活剂，可诱导Nurr1和DA 基因表达。

CAS号

178946-89-9

分子式

C23H17ClN2

主要靶点

Apoptosis|Others

仅限科研使用

Cat No : CM05481

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Synonyms

验证数据展示

  • CAS No.: 178946-89-9

    C-DIM12
    CAS#: 178946-89-9

产品信息

C-DIM12 induced expression of Nurr1-regulated genes. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA.

CAS号 178946-89-9
分子式 C23H17ClN2
主要靶点 Apoptosis|Others
主要通路 其他|凋亡
分子量 356.85
纯度 99.15%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

C-DIM12 has the neuroprotective activity in MPTPp-treated mice[2].

体外活性

C-DIM12 induces Nurr1 and DA gene expression in cell lines and primary neurons[3]. C-DIM12 suppresses astrocyte inflammatory signaling in vitro. C-DIM12 inhibits lipopolysaccharide (LPS)–induced expression of NF-κB-regulated genes in BV-2 microglia including nitric oxide synthase (NOS2), interleukin-6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2), and the effects were attenuated by Nurr1-RNA interference. Additionally, C-DIM12 decreased NF-κB activation in NF-κB–GFP (green fluorescent protein) reporter cells and enhanced nuclear translocation of Nurr1 primary microglia. C-DIM12 decreases lipopolysaccharide-induced p65 binding to the NOS2 promoter and concurrently enhanced binding of Nurr1 to the p65-binding site. C-DIM12 also stabilized binding of the Corepressor for Repressor Element 1 Silencing Transcription Factor (CoREST) and the Nuclear Receptor Corepressor 2 (NCOR2)[2].

溶解度

Ethanol:35.7 mg/mL (100 mM),DMSO:35.7 mg/mL (100 mM)

细胞实验

NF-κB–GFP HEK cells are exposed to 30 ng/ml of TNFα in the presence of 100 μM C-DIM12 for up to 24 hours. C-DIM12 is efficient at blocking NF-κB–GFP expression in the NF-κB–GFP HEK cells after TNFα treatment, displaying a statistically significant reduction in total GFP fluorescence per cell.(Only for Reference)

参考文献

1.De Miranda BR, et al. Toxicol Sci. 2015, 143(2):360-373.
2.De Miranda BR, et al. Mol Pharmacol. 2015, 87(6):1021-1034.
3.Hammond SL, et al. Neurosci Lett. 2015, 607:83-89.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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=
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C1   V1   C2   V2