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C-DIM12

CAS号

178946-89-9

分子式

C23H17ClN2

主要靶点

Apoptosis|Others

仅限科研使用

Cat No : CM05481

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Synonyms

Apoptosis|C DIM12|CDIM12|C-DIM12|C-DIM-12|inhibit|Nurr1|Inhibitor

验证数据展示

  • CAS No.: 178946-89-9

    C-DIM12
    CAS#: 178946-89-9

产品信息

CAS号 178946-89-9
分子式 C23H17ClN2
主要靶点 Apoptosis|Others
主要通路 凋亡
分子量 356.85
纯度 99.44%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Apoptosis|C DIM12|CDIM12|C-DIM12|C-DIM-12|inhibit|Nurr1|Inhibitor

体内活性

C-DIM12在MPTPp处理的小鼠中具有神经保护活性[2]。

体外活性

C-DIM12在细胞系和原代神经元中诱导Nurr1和DA基因表达[3]。此化合物还能抑制体外星形胶质细胞的炎症信号。C-DIM12抑制脂多糖(LPS)诱导的BV-2微胶质细胞中NF-κB调控基因的表达，包括一氧化氮合酶(NOS2)、白细胞介素-6(IL-6)及趋化因子(C-C动机)配体2(CCL2)，其效果通过Nurr1-RNA干扰而减弱。此外，C-DIM12降低了NF-κB-GFP（绿色荧光蛋白）报告细胞中NF-κB的激活，并增强了Nurr1在原代小胶质细胞核内的转移。C-DIM12减少了脂多糖诱导的p65与NOS2启动子的结合，并同时增强了Nurr1与p65结合位点的结合。C-DIM12还稳定了对抑制因子1沉默转录因子（CoREST）和核受体辅助抑制蛋白2（NCOR2）[2]的结合。

溶解度

Ethanol:35.7 mg/mL (100 mM);DMSO:50 mg/mL (140.11 mM)

细胞实验

NF-κB–GFP HEK cells are exposed to 30 ng/ml of TNFα in the presence of 100 μM C-DIM12 for up to 24 hours. C-DIM12 is efficient at blocking NF-κB–GFP expression in the NF-κB–GFP HEK cells after TNFα treatment, displaying a statistically significant reduction in total GFP fluorescence per cell.(Only for Reference)

参考文献

1.De Miranda BR, et al. Toxicol Sci. 2015, 143(2):360-373.
2.De Miranda BR, et al. Mol Pharmacol. 2015, 87(6):1021-1034.
3.Hammond SL, et al. Neurosci Lett. 2015, 607:83-89.

The molarity calculator equation

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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