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Broflanilide

CAS号

1207727-04-5

分子式

C25H14BrF11N2O2

主要靶点

GABA Receptor

仅限科研使用

Cat No : CM10953

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Synonyms

γ-Aminobutyric acid Receptor|溴虫氟苯双酰胺|Inhibitor|Gamma-aminobutyric acid Receptor|GABA|GABA Receptor|GABAReceptor|inhibit|Broflanilide

验证数据展示

  • CAS No.: 1207727-04-5

    Broflanilide
    CAS#: 1207727-04-5

产品信息

CAS号 1207727-04-5
分子式 C25H14BrF11N2O2
主要靶点 GABA Receptor
主要通路 离子通道|神经科学
分子量 663.29
纯度 98.95%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 γ-Aminobutyric acid Receptor|溴虫氟苯双酰胺|Inhibitor|Gamma-aminobutyric acid Receptor|GABA|GABA Receptor|GABAReceptor|inhibit|Broflanilide

靶点活性

GlyR α1 (A288Gβ):0.706 μM|GlyR α1 (A288G):0.149 μM|GABAA α1β3γ2:3 μM(mammalian)|GlyR:3 μM(human)|GABA receptor:1.3 nM(S. litura RDL)

体外活性

Broflanilide 作为一种杀虫剂，其代谢产物为desmethyl-broflanilide。Desmethyl-broflanilide对人类GABAA α1β2γ2受体、哺乳动物GABAA α1β3γ2受体以及人类甘氨酸受体(GlyR) α1β的抑制活性较弱，其IC50均大于3 μM。此外，Broflanilide 对GlyR α1-A288Gβ和GlyR α1-A288G的抑制作用较为弱，其IC50分别为0.706 μM和0.149 μM。

溶解度

DMSO:225 mg/mL (339.22 mM)

参考文献

1.Nakao T, et al. Broflanilide: A meta-diamide insecticide with a novel mode of action. Bioorg Med Chem. 2016 Feb 1;24(3):372-7.

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