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Bisantrene

Bisantrene (CL216942) 是一种具有抗肿瘤活性的蒽基双腙，可靶向作用于真核生物的 II 型拓扑异构酶。它插入并破坏 DNA 的构型，导致 DNA 单链断裂、DNA-蛋白质交联和 DNA 复制的抑制。

CAS号

78186-34-2

分子式

C22H22N8

主要靶点

Topoisomerase

仅限科研使用

Cat No : CM06699

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Synonyms

比生群|CL216942

验证数据展示

  • CAS No.: 78186-34-2

    Bisantrene
    CAS#: 78186-34-2

产品信息

Bisantrene is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.

CAS号 78186-34-2
分子式 C22H22N8
主要靶点 Topoisomerase
主要通路 DNA损伤和修复
分子量 398.46
纯度 96.07%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 比生群|CL216942

溶解度

DMSO:1 mg/mL (2.51 mM),ultrasonic and warming and heat to 80°C,H2O:0.1 mg/mL (0.25 mM),ultrasonic and warming and heat to 50°C

参考文献

1.Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54(6):1036-45.
2.Yap HY, et al. Bisantrene, an active new drug in the treatment of metastatic breast cancer. Cancer Res. 1983 Mar;43(3):1402-4.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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