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Bilastine

Bilastine (Bilaxten) 是新型抗组胺药，对H1组胺受体具有高度选择性，起效快，作用时间长的特性，可用于变应性鼻结膜炎和荨麻疹。

CAS号

202189-78-4

分子式

C28H37N3O3

主要靶点

Histamine Receptor

仅限科研使用

Cat No : CM00096

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Synonyms

Bilaxten|比拉斯汀

验证数据展示

  • CAS No.: 202189-78-4

    Bilastine
    CAS#: 202189-78-4

产品信息

Bilastine is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action.

CAS号 202189-78-4
分子式 C28H37N3O3
主要靶点 Histamine Receptor
主要通路 神经科学|G蛋白偶联受体|免疫与炎症
分子量 463.62
纯度 99.61%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Bilaxten|比拉斯汀

靶点活性

H1 receptor(in guinea-pig cerebellum):44.15 nM(Ki)

体内活性

In patients with allergic rhinoconjunctivitis, Bilastine is efficacious in all nasal symptoms including obstruction and in eye symptoms. In the fasting state, Bilastine is quickly absorbed, but the absorption is slowed when it is taken with food or fruit juice.

体外活性

Bilastine has a highly selective affinity for the H1-receptor but a very low affinity for 30 other tested receptors. It isn't obvious inhibitory against bradykinin, serotonin, muscarinic M3-receptors, leukotriene D4, calcium, α1-adrenoceptors, β2-adrenoceptors, and H2- and H3- receptors.

溶解度

DMSO:Slightly soluble

参考文献

1.Wolthers OD.Bilastine: a new nonsedating oral H1 antihistamine for treatment of allergic rhinoconjunctivitis and urticaria.Biomed Res Int. 2013;2013:626837.

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