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Betulinic acid

CAS号

472-15-1

分子式

C30H48O3

主要靶点

Endogenous Metabolite|Aminopeptidase|Apoptosis|Mitophagy|Autophagy|HIV Protease|NF-κB|Topoisomerase

仅限科研使用

Cat No : CM00703

Print datasheet

Synonyms

Apoptosis|Aminopeptidase N|ALS357|ALS-357|ALS 357|Autophagy|Betulic acid|Betulinic acid|Eukaryotic topoisomerase I|EndogenousMetabolite|Human immunodeficiency virus|HIV-1|HIVProtease|HIV Protease|HIV|inhibit|Endogenous Metabolite|桦木酸|Topoisomerase|白桦脂酸|Inhibitor|Lupatic acid|Mitophagy|Mitochondrial Autophagy|NFκB|NF-kB|NFkB|NF-κB|Nuclear factor-kappaB|Nuclear factor-κB

验证数据展示

  • CAS No.: 472-15-1

    Betulinic acid
    CAS#: 472-15-1

产品信息

CAS号 472-15-1
分子式 C30H48O3
主要靶点 Endogenous Metabolite|Aminopeptidase|Apoptosis|Mitophagy|Autophagy|HIV Protease|NF-κB|Topoisomerase
主要通路 NF-κB 信号通路|凋亡|自噬|代谢|微生物学|蛋白酶体|代谢|DNA 损伤和修复|自噬
分子量 456.7
纯度 99.7%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Apoptosis|Aminopeptidase N|ALS357|ALS-357|ALS 357|Autophagy|Betulic acid|Betulinic acid|Eukaryotic topoisomerase I|EndogenousMetabolite|Human immunodeficiency virus|HIV-1|HIVProtease|HIV Protease|HIV|inhibit|Endogenous Metabolite|桦木酸|Topoisomerase|白桦脂酸|Inhibitor|Lupatic acid|Mitophagy|Mitochondrial Autophagy|NFκB|NF-kB|NFkB|NF-κB|Nuclear factor-kappaB|Nuclear factor-κB

靶点活性

Aminopeptidase N:7.3 μM|Topo I (eukaryotic):5 μM|HIV-1:1.4 μM(EC50)

体内活性

作为抗黑色素瘤剂,Betulinic acid可抑制氨肽酶N的活性（IC50：7.3 μM）。通过阻断H9淋巴细胞中HIV复制（EC50：1.4 μM）和未感染的H9细胞生长（IC50：13 μM）的抑制,Betulinic acid产生抗HIV活性。Betulinic acid还是十分有潜力的抗肿瘤候选药物,对真核生物拓扑异构酶I的活性有抑制作用（IC50：5 μM）。

体外活性

在无胸腺裸鼠LNCaP细胞中,Betulinic acid对前列腺癌细胞和肿瘤(异种移植)的生长有抑制效果,该作用部分是由于蛋白酶依赖性Sp1/3/4及一些SP-调节基因的下调.

溶解度

H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:10 mg/mL (21.9 mM);DMSO:33.3 mg/mL (72.98 mM)

参考文献

1.Fujioka T, et al. J Nat Prod, 1994, 57(2), 243-247.
2.Melzig MF, et al. Planta Med, 1998, 64(7), 655-657.
3.Chowdhury AR, et al. Med Sci Monit, 2002, 8(7), BR254-265.
4.Chintharlapalli S, et al. Cancer Res, 2007, 67, 2816-2823.
5.Kalra J, et al. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec 26.
6.Tangliang Zhao1*, Yi Bao1*,Xinxin Gan1, et al. DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma. Theranostics. 2019, Vol. 9, Issue 22

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2