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Bepridil hydrochloride

CAS号

68099-86-5

分子式

C24H35ClN2O

主要靶点

Calcium Channel

仅限科研使用

Cat No : CM03221

Print datasheet

Synonyms

盐酸苄普地尔|Inhibitor|CERM 1978|CERM1978|CERM-1978|Bepridil hydrochloride|Bepridil Hydrochloride|Bepridil|Calcium Channel|CalciumChannel|Ca2+ channels|Ca channels|inhibit

验证数据展示

  • CAS No.: 68099-86-5

    Bepridil hydrochloride
    CAS#: 68099-86-5

产品信息

CAS号 68099-86-5
分子式 C24H35ClN2O
主要靶点 Calcium Channel
主要通路 代谢|离子通道
分子量 403
纯度 99.71%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 盐酸苄普地尔|Inhibitor|CERM 1978|CERM1978|CERM-1978|Bepridil hydrochloride|Bepridil Hydrochloride|Bepridil|Calcium Channel|CalciumChannel|Ca2+ channels|Ca channels|inhibit

体内活性

The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered [1].

体外活性

Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM [2].

溶解度

DMSO:130 mg/mL (322.58 mM)

参考文献

1.Flaim SF, et al. Effects of bepridil hydrochloride on cardiocirculatory dynamics, coronary vascular resistance, and cardiac output distribution in normal, conscious rats. J Cardiovasc Pharmacol. 1988 Mar;11(3):363-72.
2.Li Y, et al. Bepridil blunts the shortening of action potential duration caused by metabolic inhibition via blockade of ATP-sensitive K(+) channels and Na(+)-activated K(+) channels. J Pharmacol Exp Ther. 1999 Nov;291(2):562-8.
3.Qiu M, Li Z, Chen Y, et al. Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses. Frontiers in Microbiology. 2020, 11: 504.

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