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Belvarafenib

Belvarafenib 是一种有效的泛 RAF 抑制剂，具有抗肿瘤活性，对 B-RAF、B-RAFv600E 和 C-RAF 的 IC50值分别为 56、7 和 5 nM。

CAS号

1446113-23-0

分子式

C23H16ClFN6OS

主要靶点

Raf

仅限科研使用

Cat No : CM06255

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Synonyms

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  • CAS No.: 1446113-23-0

    Belvarafenib
    CAS#: 1446113-23-0

产品信息

Belvarafenib is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

CAS号 1446113-23-0
分子式 C23H16ClFN6OS
主要靶点 Raf
主要通路 MAPK信号通路
分子量 478.93
纯度 99.44%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

B-RafV600E:7 nM|B-Raf:56 nM|C-Raf:5 nM

体外活性

Belvarafenib ?is a potent and pan RAF inhibitor with antineoplastic activity.?The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.?It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively.

溶解度

DMSO:25 mg/mL (52.2 mM)

参考文献

1.Son J B , Jung S H , Choi Ii W , et al. Thieno[3,2-d]pyrimidine derivatives having inhibitory activity on protein kinases[J]. 2015.

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