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Bcl-xL antagonist 2

CAS号

1235032-75-3

分子式

C21H16N4O3S2

主要靶点

BCL

仅限科研使用

Cat No : CM19768

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Synonyms

Bcl xL antagonist 2|BclxL antagonist 2|Bcl-xL antagonist 2|Bcl-xL

验证数据展示

  • CAS No.: 1235032-75-3

    Bcl-xL antagonist 2
    CAS#: 1235032-75-3

产品信息

CAS号 1235032-75-3
分子式 C21H16N4O3S2
主要靶点 BCL
主要通路 凋亡
分子量 436.51
纯度 99.26%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Bcl xL antagonist 2|BclxL antagonist 2|Bcl-xL antagonist 2|Bcl-xL

靶点活性

BCL-XL:0.091 μM

体内活性

Bcl-xL antagonist 2（1 mg/kg;静脉注射）在大鼠中展现了良好的药代动力学特性，具体表现为清除率（CL）为0.47 mL/min/kg，稳态体积分布（Vss）为0.16 L/kg，半衰期（t1/2）为6.0小时，生物利用度（F）为16%[1]。

溶解度

DMSO:50 mg/mL (114.54 mM)

参考文献

1.Koehler MF, et al. Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL. ACS Med Chem Lett. 2014;5(6):662-667.
2.Wang L, et al. Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor. ACS Med Chem Lett. 2020;11(10):1829-1836.

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