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Batabulin

CAS号

195533-53-0

分子式

C13H7F6NO3S

主要靶点

Microtubule Associated|Apoptosis

仅限科研使用

Cat No : CM11492

Print datasheet

Synonyms

T138067|T-138067|T 138067|巴他布林|β-tubulin|Tubulin β|polymerization|Inhibitor|inhibit|multidrug-resistant|MicrotubuleAssociated|Microtubule/Tubulin|Microtubule Associated|cytoskeleton|covalent|Cys-239|cell-cycle|Batabulin|Apoptosis|arrest|antitumor|Antimitotic

验证数据展示

  • CAS No.: 195533-53-0

    Batabulin
    CAS#: 195533-53-0

产品信息

CAS号 195533-53-0
分子式 C13H7F6NO3S
主要靶点 Microtubule Associated|Apoptosis
主要通路 细胞骨架|凋亡
分子量 371.26
纯度 99.85%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 T138067|T-138067|T 138067|巴他布林|β-tubulin|Tubulin β|polymerization|Inhibitor|inhibit|multidrug-resistant|MicrotubuleAssociated|Microtubule/Tubulin|Microtubule Associated|cytoskeleton|covalent|Cys-239|cell-cycle|Batabulin|Apoptosis|arrest|antitumor|Antimitotic

体内活性

Batabulin（40 mg/kg；i.p.；每周一次；分别在第5、12、19天；雄性无胸腺裸鼠）治疗能够有效抑制化合物敏感的CCRF-CEM肿瘤生长。

体外活性

在MCF7细胞中，Batabulin（T138067；30-300 nM；24小时）的处理显示出细胞中约25-30%的四倍体（4n）DNA含量和25-30%的细胞凋亡率。经过100 nM Batabulin作用48小时后，约50-80%的细胞群体正在经历凋亡。Batabulin与β-tubulin亚型中的特定几种形成共价结合，干扰微管聚合。在β1、β2和β4 tubulin亚型共有的Cys-239残基上。Batabulin处理的细胞形态发生改变。

溶解度

DMSO:100 mg/mL (269.35 mM)

参考文献

1.Shan B, et al. Selective, covalent modification of beta-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5686-91.

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