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BNC105

BNC105 是一种微管蛋白聚合抑制剂，具有抗增殖和破坏肿瘤血管的特性。

CAS号

945771-74-4

分子式

C20H20O7

主要靶点

Microtubule Associated

仅限科研使用

Cat No : CM05115

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Synonyms

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  • CAS No.: 945771-74-4

    BNC105
    CAS#: 945771-74-4

产品信息

BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.

CAS号 945771-74-4
分子式 C20H20O7
主要靶点 Microtubule Associated
主要通路 细胞骨架
分子量 372.37
纯度 96.57%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

溶解度

DMSO:25 mg/mL (67.14 mM),Sonification is recommended.,H2O:< 0.1 mg/mL (insoluble)

参考文献

1.Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27.
2.Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73.
3.Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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