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BLT-1

CAS号

321673-30-7

分子式

C12H23N3S

主要靶点

HCV Protease|Others

仅限科研使用

Cat No : CM06377

Print datasheet

Synonyms

Block lipid transport 1|Block lipid transport1|Block lipid transport-1|BLT 1|BLT1|BLT-1|chelator|copper|inhibit|Hepatitis C virus|high-density|HCVProtease|HDL|HCV|HCV Protease|Inhibitor|lipoproteins|lipids|neutrophil|recruitment|pro-inflammatory|Transfer|thiosemicarbazone|SR-BI|scavenger

验证数据展示

  • CAS No.: 321673-30-7

    BLT-1
    CAS#: 321673-30-7

产品信息

CAS号 321673-30-7
分子式 C12H23N3S
主要靶点 HCV Protease|Others
主要通路 微生物学|蛋白酶体
分子量 241.4
纯度 98.3%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Block lipid transport 1|Block lipid transport1|Block lipid transport-1|BLT 1|BLT1|BLT-1|chelator|copper|inhibit|Hepatitis C virus|high-density|HCVProtease|HDL|HCV|HCV Protease|Inhibitor|lipoproteins|lipids|neutrophil|recruitment|pro-inflammatory|Transfer|thiosemicarbazone|SR-BI|scavenger

体外活性

BLT-1对ldlA[mSR-BI]细胞中DiI-HDL和[3H]CE-HDL的摄取具有IC50值分别为60 nM和110 nM[1]。BLT-1能够抑制mSR-BI-t1含有的脂质体在细胞和脂质体中从[3H]CE-HDL选择性摄取[3H]CE，其IC50值分别为0.057 μM和0.098 μM[2]。在HeLa和BSC-1细胞中，BLT-1（50 μM；3小时）不会引起依赖或不依赖clathrin的胞内膜运输过程中的一般缺陷[1]。

溶解度

DMSO:38.67 mg/mL (160.19 mM)

参考文献

1.Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptorSR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15422-7.
2.Nieland TJ, et al. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 8;47(1):460-72.
3.Raldúa D, et al. BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicol Lett. 2007 Dec 10;175(1-3):1-7. Epub 2007 Aug 22.

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