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BI-78D3

BI-78D3 是底物竞争性的 JNK 抑制剂(IC50:280 nM)，对 JNK 激酶活性具有抑制作用。

CAS号

883065-90-5

分子式

C13H9N5O5S2

主要靶点

JNK

仅限科研使用

Cat No : CM04918

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Synonyms

验证数据展示

  • CAS No.: 883065-90-5

    BI-78D3
    CAS#: 883065-90-5

产品信息

BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.

CAS号 883065-90-5
分子式 C13H9N5O5S2
主要靶点 JNK
主要通路 MAPK信号通路
分子量 379.37
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

JNK:280 nM

体内活性

In animal studies, BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes[1].

体外活性

BI-78D3 Inhibits JNK interacting protein 1 (JIP1)-JNK binding and prevents JNK substrate phosphorylation[2].

溶解度

Ethanol:1.9 mg/mL (5 mM),DMSO:37.9 mg/mL (100 mM)

细胞实验

Cells are subjected to a dose range of doxorubicin concentrations in the presence or absence of a non-toxic dose (10 nM) of the small molecule JIP1-inhibitor BI-78D3. (Only for Reference)

参考文献

1.Stebbins JL, et al. Proc Natl Acad Sci U S A. 2008, 105(43):16809-16813.
2.Posthumadeboer J, et al. Oncotarget. 2012, 3(10):1169-1181.

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