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BI-1347

BI-1347 是一种有效的、选择性的 CDK8/cyclinC 抑制剂，IC50值为 1 nM，可抑制肿瘤生存，详细信息请参考 WO2017202719A1 中的产物 I-003。

CAS号

2163056-91-3

分子式

C22H20N4O

主要靶点

CDK

仅限科研使用

Cat No : CM03358

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Synonyms

验证数据展示

  • CAS No.: 2163056-91-3

    BI-1347
    CAS#: 2163056-91-3

产品信息

BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.

CAS号 2163056-91-3
分子式 C22H20N4O
主要靶点 CDK
主要通路 细胞周期
分子量 356.43
纯度 99.43%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

CDK8:1 nM (cell free)

溶解度

DMSO:120 mg/mL (336.68 mM),Sonification/heating is recommended.

参考文献

1.Harald Engelhardt, et al. New phenylpyrazolylacetamide compounds and derivatives as cdk8/cdk19 inhibitors.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2