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BCL11A antibody (mAb) (Clone BCL11A/123)

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

ICC, IF, IHC, WB

CloneNo.

BCL11A/123

Cat No : 61231,61232 61231

Synonyms

BCL11A, CTIP1, B-cell CLL lymphoma 11A, COUP-TF-interacting protein 1, is a transcriptional regulator, a myeloid and B-cell proto-oncogene, leukemogenesis, hematopoiesis, hemoglobin gene switching, Mi-2, NuRD chromatin remodeling complex, GATA1, FOG1, erythroid cells, bcl, bcl11, bcl11a, ctip, ctip1, antibody, monoclonal, sample

验证数据展示

  • BCL11A antibody (mAb) tested by Western blot. HeLa nuclear extract (35 ug per lane) probed with BCL11A antibody at 2 ug/ml dilution.

    BCL11A antibody (mAb) tested by Western blot. HeLa nuclear extract (35 ug per lane) probed with BCL11A antibody at 2 ug/ml dilution.

产品信息

Tested Applications ICC, IF, IHC, WB

Applications Validated by Active Motif: WB*: 1 – 2 ug/ml dilution *Note: we recommend the addition of 0.05% Tween 20 to all blocking solutions to reduce background.
Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen This BCL11A antibody was raised against a recombinant protein corresponding to amino acids 637-835 of BCL11A-XL (B-cell lymphoma/leukemia 11A extra long form).
Full Name BCL11A antibody (mAb) (Clone BCL11A/123)
Synonyms BCL11A, CTIP1, B-cell CLL lymphoma 11A, COUP-TF-interacting protein 1, is a transcriptional regulator, a myeloid and B-cell proto-oncogene, leukemogenesis, hematopoiesis, hemoglobin gene switching, Mi-2, NuRD chromatin remodeling complex, GATA1, FOG1, erythroid cells, bcl, bcl11, bcl11a, ctip, ctip1, antibody, monoclonal, sample
Molecular weight 100 kDa
GenBank accession numberNP_075044
RRIDAB_2793560
Purification Method Protein G Chromatography
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

背景介绍

BCL11A (B-cell CLL/lymphoma 11A) is a transcriptional regulator, a myeloid and B-cell proto-oncogene and plays important roles in leukemogenesis and hematopoiesis. BCL11A is involved in regulating hemoglobin gene expression. BCL11A regulates hemoglobin gene switching during fetal development and silencing of g-globin expression in adults. BCL11A interacts with the Mi-2/NuRD chromatin remodeling complexes, as well as the erythroid transcription factors GATA1 and FOG1. Abundant expression of full-length forms of BCL11A is developmentally restricted to adult erythroid cells.