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Pritelivir

CAS号

348086-71-5

分子式

C18H18N4O3S2

主要靶点

HSV|DNA/RNA Synthesis

仅限科研使用

Cat No : CM03737

Print datasheet

Synonyms

DNA Synthesis|DNASynthesis|inhibit|HSV|HSV-1|HSV-2|helicase|helicase primase|Herpes simplex virus|herpes|complex|BAY 57-1293|AIC 316|AIC316|AIC-316|Inhibitor|RNA Synthesis|RNASynthesis|Pritelivir|primase|viral|virus|普瑞利韦

验证数据展示

  • CAS No.: 348086-71-5

    Pritelivir
    CAS#: 348086-71-5

产品信息

CAS号 348086-71-5
分子式 C18H18N4O3S2
主要靶点 HSV|DNA/RNA Synthesis
主要通路 DNA 损伤和修复|细胞周期|微生物学
分子量 402.49
纯度 99.42%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 DNA Synthesis|DNASynthesis|inhibit|HSV|HSV-1|HSV-2|helicase|helicase primase|Herpes simplex virus|herpes|complex|BAY 57-1293|AIC 316|AIC316|AIC-316|Inhibitor|RNA Synthesis|RNASynthesis|Pritelivir|primase|viral|virus|普瑞利韦

靶点活性

HSV1/HSV2:20 nM|HSV2:20 nM

体内活性

BAY57-1293剂量依赖的直接抑制病毒解旋酶-引发酶复合物的ATPase活性。BAY57-1293对耐阿昔洛韦的单纯疱疹病毒突变体也有明显的抗病毒活性。在绿猴肾细胞中,其还可降低1型单纯性疱疹病毒引起的Aβ和P-tau。

体外活性

在小鼠和大鼠致死性散播疱疹发病模型、小鼠带状疱疹样皮肤疾病扩散模型中,BAY57-1293（0.5/15 mg/kg,p.o.）均具有较强的抗病毒活性.在小鼠眼疱疹模型中也是如此.

溶解度

Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:21.67 mg/mL (53.84 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

参考文献

1.Kleymann G, et al. Nat Med. 2002, 8(4), 392-398.
2.Betz UA, et al. Antimicrob Agents Chemother. 2002, 46(6), 1766-1772.
3.Wozniak MA, et al. Antiviral Res. 2013, 99(3), 401-404.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2