• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Bay 11-7085

CAS号

196309-76-9

分子式

C13H15NO2S

主要靶点

IκB/IKK|NF-κB|Ferroptosis|Apoptosis

仅限科研使用

Cat No : CM04719

Print datasheet

Synonyms

BAY 11-7083|Bay 117085|BAY 11-7085|Bay 11-7085|Bay 11 7085|Apoptosis|inhibit|IkB|IKK|IkB/IKK|Ferroptosis|IκB|IκBα?phosphorylation|Inhibitor|Nuclear factor-κB|Nuclear factor-kappaB|NFkB|NF-kB|NF-κB|NFκB

验证数据展示

  • CAS No.: 196309-76-9

    Bay 11-7085
    CAS#: 196309-76-9

产品信息

CAS号 196309-76-9
分子式 C13H15NO2S
主要靶点 IκB/IKK|NF-κB|Ferroptosis|Apoptosis
主要通路 NF-κB 信号通路|凋亡|凋亡|NF-κB 信号通路
分子量 249.33
纯度 99.83%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 BAY 11-7083|Bay 117085|BAY 11-7085|Bay 11-7085|Bay 11 7085|Apoptosis|inhibit|IkB|IKK|IkB/IKK|Ferroptosis|IκB|IκBα?phosphorylation|Inhibitor|Nuclear factor-κB|Nuclear factor-kappaB|NFkB|NF-kB|NF-κB|NFκB

靶点活性

IκBα?phosphorylation:10 μM

体内活性

BAY 11-7085与紫杉醇联用可增强对NF-κB活性的抑制,并使经紫杉醇处理细胞的存活率降低。通过抑制NF-κB,BAY11-7085可抑制TNFα诱导的粘附分子E-selectin,ICAM-1及VCAM-1的表达。BAY11-7085（10 μM）对HUVEC细胞无细胞毒性。此外,Bay11-7085与LY294002联用可协同影响PEL细胞的凋亡。

体外活性

在含Caov-3细胞的无胸腺裸鼠体内,BAY 11-7085可使紫杉醇对腹内传播和腹水产生的抑制作用增强.BAY11-7085对脑膜炎相关的NF-κB活性增加有抑制作用,改善被感染大鼠临床状态,并使脑膜炎相关的CNS并发症和脑膜炎症显著衰减.

溶解度

Ethanol:24.9 mg/mL (100 mM);DMSO:24.9 mg/mL (100 mM)

细胞实验

Human umbilical vein endothelial cells (HUVEC) are isolated and maintained in culture. Cell toxicity is assessed by morphology and by MTT assay.(Only for Reference)

参考文献

1.Pierce JW, et al. J Biol Chem. 1997, 272(34), 21096-21103.
2.Koedel U, et al. J Infect Dis. 2000, 182(5), 1437-1445.
3.Mabuchi S, et al. Clin Cancer Res. 2004, 10(22), 7645-7654.
4.Hussain AR, et al. PLoS One. 2012, 7(6), e39945.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2