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BAY 11-7082

BAY 11-7082 是一种 NF-κB 抑制剂，可抑制 TNFα 诱导的 IκBα 磷酸化。 它抑制泛素特异性蛋白酶 USP7 和 USP21。

CAS号

19542-67-7

分子式

C10H9NO2S

主要靶点

Autophagy|Apoptosis|Others|DUB|IκB/IKK

仅限科研使用

Cat No : CM04718

Print datasheet

Synonyms

BAY 11-7821

验证数据展示

  • CAS No.: 19542-67-7

    BAY 11-7082
    CAS#: 19542-67-7

产品信息

BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.

CAS号 19542-67-7
分子式 C10H9NO2S
主要靶点 Autophagy|Apoptosis|Others|DUB|IκB/IKK
主要通路 DNA损伤和修复|NF-κB信号通路|细胞周期|凋亡|泛素化|其他|自噬
分子量 207.25
纯度 97.91%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 BAY 11-7821

靶点活性

IκBα phosphorylation:10 μM

体外活性

在NCI-H1703细胞中, BAY 11-7082（8 μM）能够抑制细胞增殖。在HTLV-I感染的T细胞系中,Bay 11-7082（5 μM）能够抑制NF-κB的DNA结合,并下调抗凋亡基因Bcl-x（L）的表达。在选择性诱导HTLV-1感染的T细胞系中, Bay11-7082（5 μM）能够引起细胞凋亡。在小鼠海马切片中,BAY 11-7082（100 μM）抑制NMDA诱导的NF-κB结合的增加,同时阻止NMDA引起的p65核转位。在骨骼肌中,BAY 11-7082（50-100 μM）显着抑制NF-κBp65 DNA结合活性。

溶解度

Ethanol:5.2 mg/mL (25 mM),DMSO:20.7 mg/mL (100 mM)

细胞实验

Cells are transfected with siRNA in 96-well microtiter plates and then cultured for 72 hours in complete NSCLC medium, treated with BAY 11-7082 for 12 hours. Cells are incubated with [3H]thymidine for 3 hours. The cells are collected on filters using an automatic cell harvester and radioactivity on the filters is measured by β-scintillation counting.(Only for Reference)

参考文献

1.Melisi D, et al. Expert Opin Ther Targets, 2007, 11(2), 133-144.
2.Gao J, Wang Y, Zhang W, et al. C20orf27 Promotes Cell Growth and Proliferation of Colorectal Cancer via the TGFβR-TAK1-NFĸB Pathway[J]. Cancers. 2020, 12(2): 336.
3.Gastonguay A, et al. Cancer Biol Ther, 2012, 13(8), 647-656.
4.Miwatashi S, et al. J Med Chem, 2005, 48(19), 5966-5979.
5.Mori N, et al. Blood, 2002, 100(5), 1828-1834.
6.Goffi F, et al. Neurosci Lett, 2005, 377(3), 147-151.
7.Jun Jacob Hu, et al. Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D. The Preprint Server For Biology, 2018,Jul. 10.
8.Shen S C, He F, Cheng C, et al. Uric acid aggravates myocardial ischemia–reperfusion injury via ROS/NLRP3 pyroptosis pathway[J]. Biomedicine & Pharmacotherapy . 2020, 133: 110990.
9.Yu Y, Li Z, Guo R, et al. Ononin, sec-O-β-D-glucosylhamaudol and astragaloside I: antiviral lead compounds identified via high throughput screening and biological validation from traditional Chinese medicine Zhongjing formulary[J]. Pharmacological Research. 2019 May 11;145:104248.

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