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Astragaloside A

Astragaloside A (Astramembrannin I) 是从黄芪中分离得到的初级纯皂苷，已广泛用于心血管疾病的治疗。

CAS号

83207-58-3

分子式

C41H68O14

主要靶点

Calcium Channel

仅限科研使用

Cat No : CM05146

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Synonyms

Astramembrannin I|黄芪甲苷|Astragalin A

验证数据展示

  • CAS No.: 83207-58-3

    Astragaloside A
    CAS#: 83207-58-3

产品信息

Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the therapy of cardiovascular diseases.

CAS号 83207-58-3
分子式 C41H68O14
主要靶点 Calcium Channel
主要通路 离子通道|代谢
分子量 784.97
纯度 99.87%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Astramembrannin I|黄芪甲苷|Astragalin A

体内活性

Astragaloside IV significantly reduces infarct size in dogs subjected to coronary ligation in vivo. [1] Astragaloside IV attenuates isoproterenol-induced subendocardial necrosis, serum lactate dehydrogenase and creatine kinase activation, and lipid oxide product malondialdehyde formation in rats. It also reduces sarcoplasmic reticulum Ca(2+)-uptake ability and Ca(2+)-ATPase (SERCA2a) activity as well as SERCA2a mRNA expression in myocardial injury rats. [2]

体外活性

Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester. [1]

溶解度

DMSO:93 mg/mL (118.5 mM),Ethanol:<1 mg/mL,H2O:<1 mg/mL

参考文献

1.Zhang WD, et al. Planta Med, 2006, 72(1), 4-8.
2.Xu, X.L, et al. Eur J Pharmacol, 2007, 568(1-3), 203-212.

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The dilution calculator equation

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