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Umifenovir hydrochloride

Umifenovir hydrochloride (Arbidol HCl) 是一种口服有效的广谱抗病毒药物，对多种包膜和非包膜病毒均有活性。它被用作抗流感病毒剂，可通过阻断病毒与宿主细胞膜的融合来抑制包膜病毒的细胞侵袭。它是一种 SARS-CoV-2 抑制剂，具有抗炎活性。

CAS号

131707-23-8

分子式

C22H25BrN2O3S·HCl

主要靶点

SARS-CoV|Influenza Virus

仅限科研使用

Cat No : CM04760

Print datasheet

Synonyms

Arbidol HCl|盐酸阿比朵尔|Arbidol hydrochloride|盐酸阿比多尔

验证数据展示

  • CAS No.: 131707-23-8

    Umifenovir hydrochloride
    CAS#: 131707-23-8

产品信息

Arbidol (Umifenovir) hydrochloride, an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane.

CAS号 131707-23-8
分子式 C22H25BrN2O3S·HCl
主要靶点 SARS-CoV|Influenza Virus
主要通路 微生物学
分子量 513.88
纯度 99.88%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Arbidol HCl|盐酸阿比朵尔|Arbidol hydrochloride|盐酸阿比多尔

靶点活性

enveloped and non-enveloped RNA viruses(FLU-A, RSV, HRV 14 and CVB3):2.7-13.8 microg/ml

体外活性

Arbidol inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent fashion. Arbidol also displays a dose-dependent inhibition of HCV membrane fusion, as assayed by using HCV pseudoparticles (HCVpp) and fluorescent liposomes. [1] Arbidol is found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with IC50 ranging from 2.7 to 13.8 mg/mL. Arbidol shows selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5). [2] Arbidol induces changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34. [3] Arbidol interacts and modifies the physicochemical properties of the phospholipids in the membrane, having a significant effect on negatively charged phospholipids but a minor one on zwitterionic phospholipids. Arbidol is located at the interface of the membrane, participates in hydrogen bonding either with water or the phospholipid or both, and decreases the hydrogen bonding network of the phospholipids giving place to a phospholipid phase similar to the dehydrated solid one. [4] Arbidol is found to have potent inhibitory activity against HTNV when added in vitro before or after viral infection, with IC50 of 0.9 mg/mL and 1.2 mg/mL, respectively. [5]

溶解度

DMSO:95 mg/mL (184.9 mM),H2O:<1 mg/mL,Ethanol:21 mg/mL (40.9 mM)

参考文献

1.Pécheur EI, et al. Biochemistry, 2007, 46(20), 6050-6059.
2.Shi L, et al. Arch Virol, 2007, 152(8), 1447-1455.
3.Brooks MJ, et al. J Med Virol, 2012, 84(1), 170-181.
4.Villalaín J, et al. J Phys Chem B. 2010 Jul 1;114(25):8544-54.
5.Deng HY, et al. Acta Pharmacol Sin, 2009, 30(7), 12015-1024.
6.Li J, Hu Y, Yuan Y, et al. Repurposing of Antazoline Hydrochloride as an Inhibitor of Hepatitis B Virus DNA Secretion[J]. Virologica Sinica. 2020: 1-9.

The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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