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Arbidol

Arbidol (Umifenovir) 是一种具有口服活性广谱抗病毒化合物，属于融合抑制剂，可与 SARS-CoV-2 刺突蛋白相互作用。Arbidol 对多种冠状病毒显示出抑制活性。Arbidol 具有抗炎抗氧化活性，可用于研究浓度感染。

CAS号

131707-25-0

分子式

C22H25BrN2O3S

主要靶点

SARS-CoV

仅限科研使用

Cat No : CM21355

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Synonyms

阿比朵尔, Umifenovir

验证数据展示

  • CAS No.: 131707-25-0

    Arbidol
    CAS#: 131707-25-0

产品信息

Arbidol (Umifenovir) is an orally active broad-spectrum antiviral compound that is a fusion inhibitor and interacts with the SARS-CoV-2 spicule protein.Arbidol shows inhibitory activity against a variety of coronaviruses.Arbidol has anti-inflammatory and antioxidant activity and may be useful for the study of concentrated infections.

CAS号 131707-25-0
分子式 C22H25BrN2O3S
主要靶点 SARS-CoV
主要通路 其他
分子量 477.42
纯度 99.57%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
别名 阿比朵尔, Umifenovir

体内活性

Arbidol（25 和 45 mg/ml；口服；6-8 周龄 BALB/c 小鼠）对感染流感病毒的小鼠表现出存活益处。与病毒组相比，Arbidol 提高了小鼠的存活率，在 45 mg/mL 剂量下抑制了小鼠体重下降，在 25 mg/mL 和 45 mg/mL 剂量下抑制了小鼠肺指数的增加。[3]

体外活性

Arbidol 对多种病毒具有强大的抗病毒活性，包括流感病毒 A、B 和 C、呼吸道合胞病毒、SARS-CoV、腺病毒、副流感病毒 5 型、脊髓灰质炎病毒 1、鼻病毒 14、柯萨奇病毒 B5、汉坦病毒、基孔肯雅病毒、HBV 和 HCV。[1]

参考文献

1.Blaising J, et al. Arbidol as a broad-spectrum antiviral: an update. Antiviral Res. 2014 Jul;107:84-94.
2.Leneva I, et al. Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus. Viruses. 2021 Aug 23;13(8):1665.
3.Wang Y, et al. Inhibition of the infectivity and inflammatory response of influenza virus by Arbidol hydrochloride in vitro and in vivo (mice and ferret). Biomed Pharmacother. 2017 Jul;91:393-401.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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