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Antazoline hydrochloride

Antazoline hydrochloride (Phenazoline hydrochloride) 是一种抗组胺药，可与组胺H1受体结合，阻断内源性组胺的作用。它也具有抗胆碱能特性，可缓解鼻塞，也可用作眼药水。

CAS号

2508-72-7

分子式

C17H19N3·HCl

主要靶点

Histamine Receptor

仅限科研使用

Cat No : CM04479

Print datasheet

Synonyms

Phenazocine HCl|Phenazoline hydrochloride|盐酸安他唑啉|Antazoline HCl

验证数据展示

  • CAS No.: 2508-72-7

    Antazoline hydrochloride
    CAS#: 2508-72-7

产品信息

Antazoline hydrochloride, a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine.

CAS号 2508-72-7
分子式 C17H19N3·HCl
主要靶点 Histamine Receptor
主要通路 神经科学|免疫与炎症|G蛋白偶联受体
分子量 301.82
纯度 99.76%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Phenazocine HCl|Phenazoline hydrochloride|盐酸安他唑啉|Antazoline HCl

体内活性

30 μM Antazoline即可降低由NMDA介导的神经毒性,还可阻断NMDA电流依赖的电压和快速可逆作用,电压在 -60 mV下抑制率为85±3%。

体外活性

在帧内梨形毛果芸香碱诱导的持续癫痫状态模型中,Antazoline可用来保护体内的神经.

溶解度

Ethanol:4 mg/mL (13.25 mM),H2O:14 mg/mL (46.38 mM),DMSO:40 mg/mL (132.53 mM)

参考文献

1.Milhaud D, et al. Neuroscience, 2003, 120(2), 475-484.
2.Li J, Hu Y, Yuan Y, et al. Repurposing of Antazoline Hydrochloride as an Inhibitor of Hepatitis B Virus DNA Secretion[J]. Virologica Sinica. 2020: 1-9.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2