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Antalarmin hydrochloride

Antalarmin hydrochloride 是促肾上腺皮质激素释放因子 1 (CRF1) 的拮抗剂。 Antalarmin hydrochloride 具有抗炎作用并抑制与肠易激综合征相关的应激性胃溃疡。

CAS号

220953-69-5

分子式

C24H35ClN4

主要靶点

CRFR|Immunology/Inflammation related

仅限科研使用

Cat No : CM07559

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Synonyms

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  • CAS No.: 220953-69-5

    Antalarmin hydrochloride
    CAS#: 220953-69-5

产品信息

Antalarmin hydrochloride is an antagonist of corticotropin-releasing factor 1(CRF1). Antalarmin hydrochloride produces anti-inflammatory effects and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.

CAS号 220953-69-5
分子式 C24H35ClN4
主要靶点 CRFR|Immunology/Inflammation related
主要通路 免疫与炎症|G蛋白偶联受体
分子量 415.02
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

溶解度

DMSO:11.7mg/mL (28.2mM),Sonification is recommended.

参考文献

1.Zorrilla EP, et al. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res. 2002 Oct 18;952(2):188-99.
2.Deak T, et al. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. Endocrinology. 1999 Jan;140(1):79-86.
3.Webster EL, et al. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology. 1996 Dec;137(12):5747-50.

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