• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Ansamitocin p-3

Ansamitocin p-3 (Maytansinol isobutyrate) 是一种微管抑制剂，对微管蛋白聚合的 IC50 为 3.4 μM。

CAS号

66584-72-3

分子式

C32H43ClN2O9

主要靶点

Microtubule Associated

仅限科研使用

Cat No : CM05113

Print datasheet

Synonyms

Antibiotic C 15003P3|Maytansinol isobutyrate|NSC292222

验证数据展示

  • CAS No.: 66584-72-3

    Ansamitocin p-3
    CAS#: 66584-72-3

产品信息

Ansamitocin p-3 is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization.

CAS号 66584-72-3
分子式 C32H43ClN2O9
主要靶点 Microtubule Associated
主要通路 细胞骨架
分子量 635.15
纯度 99.73%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Antibiotic C 15003P3|Maytansinol isobutyrate|NSC292222

体外活性

Ansamitocin p-3 inhibits the proliferation in a concentration-dependent manner with IC50s of 20, 50, 140, and 150 pM for MCF-7, HeLa, EMT-6/AR1, and MDA-MB-231 cells in culture, respectively. Ansamitocin P3 binds to purified tubulin (Kd = 1.3 µM)[1].

溶解度

DMSO:90.0 mg/mL (141.7 mM)

参考文献

1.Kiso T, et al. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrob Agents Chemother. 2004 May;48(5):1739-48
2.Venghateri JB, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at thevinblastine site. PLoS One. 2013 Oct 4;8(10):e75182.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2