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Angiotensin II human

Angiotensin II 是一种主要的生物活性血管收缩肽，通过与AT1R和AT2R受体结合，调节血压，刺激交感神经，促进醛固酮合成和肾脏功能。它还能诱导血管平滑肌细胞增生、胶原合成增加，导致血管和心肌增厚及纤维化，同时促进细胞凋亡和内皮细胞毛细血管形成。Angiotensin II常用于诱导高血压和心脏肥大动物模型。

CAS号

4474-91-3

分子式

C50H71N13O12

主要靶点

RAAS|Apoptosis

仅限科研使用

Cat No : CM00075

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Synonyms

Hypertensin II|inhibit|Inhibitor|Apoptosis|Ang II|AT receptor|Angiotensin Receptor|Angiotensin II human|Angiotensin II|DRVYIHPF|血管紧张素Ⅱ|血管紧张素II

验证数据展示

  • CAS No.: 4474-91-3

    Angiotensin II human
    CAS#: 4474-91-3

产品信息

Angiotensin II is a major biologically active vasoconstrictor peptide that regulates blood pressure by binding to AT1R and AT2R receptors. It stimulates the sympathetic nervous system, promotes aldosterone synthesis, and enhances renal function. Additionally, it induces vascular smooth muscle cell proliferation and increases collagen synthesis, leading to vascular and myocardial hypertrophy and fibrosis. It also promotes apoptosis and endothelial capillary formation. Angiotensin II is commonly used to induce hypertension and cardiac hypertrophy animal models.

CAS号 4474-91-3
分子式 C50H71N13O12
主要靶点 RAAS|Apoptosis
主要通路 凋亡|内分泌与激素
分子量 1046.18
纯度 99.99%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
别名 Hypertensin II|inhibit|Inhibitor|Apoptosis|Ang II|AT receptor|Angiotensin Receptor|Angiotensin II human|Angiotensin II|DRVYIHPF|血管紧张素Ⅱ|血管紧张素II

靶点活性

CHO cells viability:0.52 nM (EC50)|CHO cells viability:1.5 nM

体内活性

方法：为在人类高血压小鼠模型中测定胰岛素作用，使用渗透微型泵将 Angiotensin II (1.1 mg/kg in 0.9% saline) 给药给 C57Bl/6J 小鼠，持续二-四周。 结果：Angiotensin II 治疗后血压升高。葡萄糖给药后，Angiotensin II 治疗的小鼠的血清胰岛素增加幅度更大。长期 Angiotensin II 治疗四周可增强小鼠葡萄糖刺激的胰岛素分泌。[3] 方法：为分析体内遗传毒性效应，使用渗透微型泵将 Angiotensin II (60 ng/kg/min-1 μg/kg/min) 给药给 C57Bl/6J 小鼠，持续四周。 结果：Angiotensin II 使 SBP 比对照组高达 38 mmHg，并对小鼠的肾功能产生不利影响。在心脏中，在最高给药剂量下，可以检测到活性氧形成的显著增加和双链断裂。在肾脏中，观察到超氧化物形成的剂量依赖性增加、双链断裂和 DNA 碱基修饰突变。[4]

体外活性

方法：人肝癌细胞 (HCC) HepG-2、SMMC-7721、MHCC97-H 用 Angiotensin II (1-1000 nM) 处理 24-72 h，使用 MTT 方法检测的细胞活力。 结果：Angiotensin II 诱导 HCC 细胞系以时间和浓度依赖的方式显示出更高的生长。[1] 方法：新生大鼠心肌细胞用 Angiotensin II (1 μmol/L) 处理 5 min-48 h，使用 ELISA 和 RT-qPCR 方法检测 HMGB1 和 IL-6 表达水平。 结果：Angiotensin II 增强心肌细胞中 HMGB1 和 IL-6 的表达水平。[2]

溶解度

DMSO:< 1 mg/mL (insoluble);H2O:10.52 mg/mL (10.06 mM)

动物实验

(129×C57BL/6) F1 mice, which lack AT1A receptors Angiotensin II used, are fed 10 gm/day gelled 0.25% NaCl diet that contains all nutrients and water. After 28 days of Angiotensin II infusion, hearts are harvested, weighed fixed in formalin, sectioned, and stained with Masson trichrome.

参考文献

1.Ji Y, et al. Angiotensin II Enhances Proliferation and Inflammation through AT1/PKC/NF-κB Signaling Pathway in Hepatocellular Carcinoma Cells. Cell Physiol Biochem. 2016 Jul;39(1):13-32.
2.Zhang L, et al. Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload. Int Heart J. 2021 Jan 30;62(1):162-170.
3.Gletsu N, et al. Angiotensin II-induced hypertension in mice caused an increase in insulin secretion. Vascul Pharmacol. 2005 Feb;42(3):83-92.
4.Brand S, et al. Angiotensin II-induced hypertension dose-dependently leads to oxidative stress and DNA damage in mouse kidneys and hearts. J Hypertens. 2013 Feb;31(2):333-44.
5.Zhang R Y, Wu C M, Hu X M, et al. LncRNA AC105942. 1 Downregulates hnRNPA2/B1 to Attenuate Vascular Smooth Muscle Cells Proliferation[J]. DNA and Cell Biology. 2021

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