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Adapalene

CAS号

106685-40-9

分子式

C28H28O3

主要靶点

Retinoid Receptor|Apoptosis|Autophagy

仅限科研使用

Cat No : CM00647

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Synonyms

GOT1|Autophagy|CD 271|CD271|CD-271|acne|Adapalene|Apoptosis|RXR|tumor|阿达帕林|Retinoid Receptor|Retinoid X receptors|Retinoic acid receptors|retinoid|RAR|RAR/RXR|RARγ|RARα|RARβ|RetinoidReceptor|Inhibitor|inhibit

验证数据展示

  • CAS No.: 106685-40-9

    Adapalene
    CAS#: 106685-40-9

产品信息

CAS号 106685-40-9
分子式 C28H28O3
主要靶点 Retinoid Receptor|Apoptosis|Autophagy
主要通路 代谢|凋亡|自噬
分子量 412.52
纯度 99.76%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 GOT1|Autophagy|CD 271|CD271|CD-271|acne|Adapalene|Apoptosis|RXR|tumor|阿达帕林|Retinoid Receptor|Retinoid X receptors|Retinoic acid receptors|retinoid|RAR|RAR/RXR|RARγ|RARα|RARβ|RetinoidReceptor|Inhibitor|inhibit

靶点活性

RARβ:2.3 nM (AC50)|RARγ:9.3 nM (AC50)|RARα:22 nM (AC50)

体内活性

在结肠癌细胞系CC-531,HT-29和LOVO以及人类包皮成纤维细胞中,Adapalene能诱导肿瘤细胞中的胱天蛋白酶-3活性,以时间和剂量依赖性地抑制的DNA合成,并诱导细胞凋亡。

体外活性

在rhino小鼠中,Adapalene引起表皮黑头粉素数量减少,表皮厚度的增加.正常皮肤和痤疮外植体的外植体中,Adapalene降低TLR-2和IL-10的表达.Adapalene通过增加CD1d表达和降低角质形成细胞的IL-10表达,调节表皮免疫系统,增加树突细胞和T淋巴细胞之间的相互作用和对抗痤疮丙酸杆菌的抗微生物活性.

溶解度

DMSO:12.5 mg/mL (30.3 mM)

参考文献

1.Brogden RN, et al. Drugs, 1997, 53(3), 511-519.
2.2. Ocker M, et al. Int J Cancer, 2003, 107(3), 453-459.
3.Tenaud I, et al. Exp Dermatol, 2007, 16(6), 500-506.

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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