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AZD-8529 mesylate

CAS号

1314217-69-0

分子式

C25H28F3N5O6S

主要靶点

GluR

仅限科研使用

Cat No : CM05084

Print datasheet

Synonyms

inhibit|AZD 8529|AZD 8529 mesylate|AZD 8529 Mesylate|AZD8529 Mesylate|AZD8529 mesylate|AZD-8529 Mesylate|AZD8529|AZD-8529|addiction|receptor|nicotine|Inhibitor|Metabotropic glutamate receptors|mGluR|mGluR2|treatment

验证数据展示

  • CAS No.: 1314217-69-0

    AZD-8529 mesylate
    CAS#: 1314217-69-0

产品信息

CAS号 1314217-69-0
分子式 C25H28F3N5O6S
主要靶点 GluR
主要通路 神经科学
分子量 583.58
纯度 99.19%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|AZD 8529|AZD 8529 mesylate|AZD 8529 Mesylate|AZD8529 Mesylate|AZD8529 mesylate|AZD-8529 Mesylate|AZD8529|AZD-8529|addiction|receptor|nicotine|Inhibitor|Metabotropic glutamate receptors|mGluR|mGluR2|treatment

靶点活性

mGluR2:（EC50）285 nM

体内活性

AZD-8529（30 mg/kg；i.p.）能够降低自由活动大鼠伏隔核壳区域因尼古丁引起的多巴胺外泌增加。同时，AZD-8529（0.3 mg/kg；i.m.）减少了松鼠猴因尼古丁原发性诱导和线索诱导的复吸行为。

体外活性

AZD-8529在mGluR2上增强谷氨酸的效应（EC50: 195 nM）。在25 μM浓度下，AZD-8529 不引发mGluRs的拮抗反应。

溶解度

DMSO:41.67 mg/mL (71.40 mM)

参考文献

1.Justinova Z, et al. The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. Biol Psychiatry. 2015 Oct 1;78(7):452-62.

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