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AUDA

AUDA 是可溶性环氧化物水解酶 (sEH) 抑制剂，在小鼠和人 sEH 的IC50分别为 18 和 69 nM，具有抗炎特性。

CAS号

479413-70-2

分子式

C23H40N2O3

主要靶点

Epoxide Hydrolase

仅限科研使用

Cat No : CM06396

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Synonyms

验证数据展示

  • CAS No.: 479413-70-2

    AUDA
    CAS#: 479413-70-2

产品信息

AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)

CAS号 479413-70-2
分子式 C23H40N2O3
主要靶点 Epoxide Hydrolase
主要通路 代谢
分子量 392.6
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

sEH:18 nM (mouse)|sEH:69 nM (human)

体内活性

AUDA increased the proliferation, migration, adhesion and tube formation ability of HCAECs in a dose-dependent manner.?Furthermore, in the mouse model of KD, AUDA reduced the protein expression of MMP-9, IL-1β and TNF-α, indicating that AUDA may alleviate inflammatory reactions in the coronary arteries of KD model mice[2].

体外活性

AUDA significantly inhibited PDGF-induced rat VSMC proliferation, which coincided with Pin1 suppression and heme oxygenase-1 (HO-1) upregulation.?However, exogenous 8,9-EET, 11,12-EET, and 14,15-EET treatments did not alter Pin1 or HO-1 levels and had little effect on the proliferation of rat VSMCs.?On the other hand, AUDA enhanced the PDGF-stimulated cell migration of rat VSMCs.?Furthermore, AUDA-induced activation of cyclooxygenase-2 (COX-2) and subsequent thromboxane A2 (TXA?) production were required for the enhanced migration[1].

溶解度

DMSO:30 mg/ml (76.41 mM)

细胞实验

Cell Line:Vascular smooth muscle cell (VSMC).Concentration:0.3, 1, 3, 10 μg/mL. Incubation Time:48 hours[1]

动物实验

AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels.Animal Model:Male (wild-type). C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g).Dosage:10 mg/kg.Administration:i.p.; 14 days[2]

参考文献

1.Hyo K , Sang K , Keon K . Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells[J]. International Journal of Molecular Sciences, 2017, 18(12):2683-.
2.Dai N, et al. Vascular repair and anti-inflammatory effects of soluble epoxide hydrolase inhibitor.Exp Ther Med. 2019 May;17(5):3580-3588.

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