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Buloxibutid

CAS号

477775-14-7

分子式

C23H29N3O4S2

主要靶点

RAAS

仅限科研使用

Cat No : CM02709

Print datasheet

Synonyms

AT2 receptor agonist C21|AT2 receptor|AT2|AT1|Buloxibutid

验证数据展示

  • CAS No.: 477775-14-7

    Buloxibutid
    CAS#: 477775-14-7

产品信息

CAS号 477775-14-7
分子式 C23H29N3O4S2
主要靶点 RAAS
主要通路 内分泌与激素
分子量 475.62
纯度 98.58%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 AT2 receptor agonist C21|AT2 receptor|AT2|AT1|Buloxibutid

靶点活性

AT2:0.4 nM(ki)|AT1:>10 μM(ki)

体内活性

Buloxibutid，在口服后的生物利用度为20-30%，在大鼠体内的半衰期估计为4小时，能够诱导神经细胞的突起生长，刺激p42/p44mapk，并在Sprague-Dawley大鼠中增强体内十二指肠碱性分泌。同时，Buloxibutid还能降低麻醉状态下自发高血压大鼠的平均动脉血压。[1]

溶解度

DMSO:22.5 mg/mL (47.31 mM)

参考文献

1.Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004 Nov 18;47(24):5995-6008.
2.Schwengel K, et al. Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice. J Mol Med (Berl). 2016;94(8):957-966.
3.Fatima N, et al. Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10. Front Pharmacol. 2021;12:600163.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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