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ASP4132

ASP4132 是一种口服活性的 AMPK 激活剂，EC50为 18 nM，具有抗癌活性。

CAS号

1640294-30-9

分子式

C46H51F3N6O8S2

主要靶点

AMPK

仅限科研使用

Cat No : CM02676

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Synonyms

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  • CAS No.: 1640294-30-9

    ASP4132
    CAS#: 1640294-30-9

产品信息

ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.

CAS号 1640294-30-9
分子式 C46H51F3N6O8S2
主要靶点 AMPK
主要通路 表观遗传|PI3K/Akt/mTOR信号通路
分子量 937.06
纯度 99.26%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

AMPK:18 nM (EC50)

溶解度

DMSO:230 mg/mL (245.45 mM),Sonification is recommended.,Methanol:8.33 mg/mL (8.89 mM),Sonification is recommended.

参考文献

1.Kazuyuki Kuramoto , Yuki Sawada, Tomohiro Yamada,et al.Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity.Chem Pharm Bull (Tokyo). 2020;68(5):452-465.
2.Kazuyuki Kuramoto, et al. Development of a Potent and Orally Active Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK), ASP4132, as a Clinical Candidate for the Treatment of Human Cancer. Bioorg Med Chem. 2020 Mar 1;28(5):115307.

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