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ASP4132

CAS号

1640294-30-9

分子式

C46H51F3N6O8S2

主要靶点

AMPK

仅限科研使用

Cat No : CM02676

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Synonyms

inhibit|AMPK|AMP-activated protein kinase|anti-cancer|ASP 4132|ASP4132|ASP-4132|breast|cancer|Inhibitor|orally|xenograft

验证数据展示

  • CAS No.: 1640294-30-9

    ASP4132
    CAS#: 1640294-30-9

产品信息

CAS号 1640294-30-9
分子式 C46H51F3N6O8S2
主要靶点 AMPK
主要通路 PI3K/Akt/mTOR 信号通路|表观遗传
分子量 937.06
纯度 99.26%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|AMPK|AMP-activated protein kinase|anti-cancer|ASP 4132|ASP4132|ASP-4132|breast|cancer|Inhibitor|orally|xenograft

靶点活性

AMPK:18 nM (EC50)

溶解度

Methanol:8.33 mg/mL (8.89 mM);DMSO:230 mg/mL (245.45 mM)

参考文献

1.Kazuyuki Kuramoto , Yuki Sawada, Tomohiro Yamada,et al.Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity.Chem Pharm Bull (Tokyo). 2020;68(5):452-465.
2.Kazuyuki Kuramoto, et al. Development of a Potent and Orally Active Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK), ASP4132, as a Clinical Candidate for the Treatment of Human Cancer. Bioorg Med Chem. 2020 Mar 1;28(5):115307.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2