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AR 231453

AR 231453 是一种口服具有活性的、特异性的 GPR119激动剂。它能够刺激细胞增殖，改善胰岛 β 细胞的功能。

CAS号

733750-99-7

分子式

C21H24FN7O5S

主要靶点

GPR

仅限科研使用

Cat No : CM04288

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Synonyms

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  • CAS No.: 733750-99-7

    AR 231453
    CAS#: 733750-99-7

产品信息

AR 231453 is a selective and orally available GPR119 agonist,can stimulate β-cell replication and improve islet graft function.

CAS号 733750-99-7
分子式 C21H24FN7O5S
主要靶点 GPR
主要通路 内分泌与激素|G蛋白偶联受体
分子量 505.52
纯度 99.45%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

溶解度

H2O:60 mg/mL (118.69 mM),Sonification/heating is recommended.,DMSO:60 mg/mL (118.69 mM)

参考文献

1.Chu ZL, et al. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology. 2008 May;149(5):2038-47.
2.Semple G, et al. Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem. 2008 Sep 11;51(17):5172-5.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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