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ADHP

CAS号

119171-73-2

分子式

C14H11NO4

主要靶点

Others

仅限科研使用

Cat No : CM19376

Print datasheet

Synonyms

inhibit|10-乙酰基-3,7-二羟基吩嗪|10-Acetyl-3,7-dihydroxyphenoxazine|ADHP|Inhibitor

验证数据展示

  • CAS No.: 119171-73-2

    ADHP
    CAS#: 119171-73-2

产品信息

CAS号 119171-73-2
分子式 C14H11NO4
主要靶点 Others
主要通路 其他
分子量 257.24
纯度 98.7%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature,store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|10-乙酰基-3,7-二羟基吩嗪|10-Acetyl-3,7-dihydroxyphenoxazine|ADHP|Inhibitor

体外活性

为了获得Compound I的Km和kcat参数，采用了两种独立方法。首先，通过内置于荧光平板阅读器的注射器功能研究ADHP的氧化反应。自动注射器注入H2O2以触发反应，生成一系列进展曲线。对MPO介导的ADHP氧化分析显示，Km为31±4 μM，kcat为186±6/s。实验中ADHP浓度范围从1到80 μM，观测速率常数kobs随之增加；在将底物浓度固定在3到45 nM MPO的对照实验中亦是如此。从kobs对ADHP浓度作图的斜率得到的表观二级速率常数Kappon为2.1±0.2 mM/s。

溶解度

DMSO:60 mg/ml (233.25 mM)

参考文献

1.Jiansheng Huang, et al. Ordered Cleavage of Myeloperoxidase Ester Bonds Releases Active site Heme Leading to Inactivation of Myeloperoxidase by Benzoic Acid Hydrazide Analogs. Arch Biochem Biophys. 2014 Apr 15; 548: 74–85.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2