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ACT-389949

CAS号

1258417-54-7

分子式

C20H18F2N6O3

主要靶点

Others

仅限科研使用

Cat No : CM04180

Print datasheet

Synonyms

FPR2/ALX|inhibit|ACT 389949|ACT389949|ACT-389949|Inhibitor

验证数据展示

  • CAS No.: 1258417-54-7

    ACT-389949
    CAS#: 1258417-54-7

产品信息

CAS号 1258417-54-7
分子式 C20H18F2N6O3
主要靶点 Others
主要通路 其他
分子量 428.39
纯度 99.40%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 FPR2/ALX|inhibit|ACT 389949|ACT389949|ACT-389949|Inhibitor

靶点活性

FPR2/ALX:3 nM(EC50)

体内活性

ACT-389949在体内得到良好耐受。该化合物在给药后约2小时达到最大浓度，平均终末半衰期为29.3小时。ACT-389949的给药可引起剂量依赖性，长效的FPR2/ALX在白细胞内的内化作用[1]。

溶解度

DMSO:10 mg/mL (23.34 mM)

参考文献

1.Stalder AK,et al. Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. Br J Clin Pharmacol. 2017 Mar;83(3):476-486.
2.Lind S, et al. Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949. Biochem Pharmacol. 2019 Aug;166:163-173.

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