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Ac-YVAD-CMK

CAS号

178603-78-6

分子式

C24H33ClN4O8

主要靶点

Immunology/Inflammation related|IL Receptor|Caspase|Pyroptosis

仅限科研使用

Cat No : CM03292

Print datasheet

Synonyms

Pyroptosis|Caspase-1|Caspase-1 Inhibitor II|Ac-Tyr-Val-Ala-Asp-chloromethylketone|Ac-Tyr-Val-Ala-Asp-CMK|Ac-YVAD-CMK|ILReceptor|IL-1β|Inflammationrelated|inflammation|Inflammation related|Immunology related|Immunologyrelated|IL Receptor

验证数据展示

  • CAS No.: 178603-78-6

    Ac-YVAD-CMK
    CAS#: 178603-78-6

产品信息

CAS号 178603-78-6
分子式 C24H33ClN4O8
主要靶点 Immunology/Inflammation related|IL Receptor|Caspase|Pyroptosis
主要通路 免疫与炎症|免疫与炎症|免疫与炎症|凋亡|蛋白酶体|凋亡
分子量 540.99
纯度 99.49%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Pyroptosis|Caspase-1|Caspase-1 Inhibitor II|Ac-Tyr-Val-Ala-Asp-chloromethylketone|Ac-Tyr-Val-Ala-Asp-CMK|Ac-YVAD-CMK|ILReceptor|IL-1β|Inflammationrelated|inflammation|Inflammation related|Immunology related|Immunologyrelated|IL Receptor

体内活性

在SD大鼠中，Ac-YVAD-cmk处理（1 μg；注射入左侧侧脑室）与ICH组相比，显著降低了caspase-1和成熟IL-1β/IL-18的蛋白水平[3]。Ac-YVAD-cmk（12.5 μmol/kg）显著减少了大鼠的死亡率，从83%降至33%[4]。

体外活性

Ac-YVAD-cmk（40和80 μM）在激活的小胶质细胞中降低了IL-1β和IL-18的表达[3]。

溶解度

DMF:10 mg/mL (18.48 mM);DMSO:90 mg/mL (166.4 mM)

参考文献

1.Rabuffetti, M., Sciorati, C., Tarozzo, G., et al. Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines. Journal of Neuroscience 20, 4398-4404 (2000).
2.Wang F, et al. Alcohol accumulation promotes esophagitis via pyroptosis activation. Int J Biol Sci. 2018;14(10):1245-1255. Published 2018 Jul 13.
3.Liang H, et al. Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats. Int Immunopharmacol. 2019;75:105771.
4.Mathiak G, et al. Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br J Pharmacol. 2000;131(3):383-386.

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