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Obefazimod

CAS号

1258453-75-6

分子式

C16H10ClF3N2O

主要靶点

HIV Protease

仅限科研使用

Cat No : CM04598

Print datasheet

Synonyms

Human immunodeficiency virus|HIVProtease|HIV Protease|HIV|ABX 464|ABX464|ABX-464|Inhibitor|inhibit|Obefazimod

验证数据展示

  • CAS No.: 1258453-75-6

    Obefazimod
    CAS#: 1258453-75-6

产品信息

CAS号 1258453-75-6
分子式 C16H10ClF3N2O
主要靶点 HIV Protease
主要通路 蛋白酶体|微生物学
分子量 338.71
纯度 99.86%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Human immunodeficiency virus|HIVProtease|HIV Protease|HIV|ABX 464|ABX464|ABX-464|Inhibitor|inhibit|Obefazimod

靶点活性

HIV-1:0.1 μM - 0.5 μM

体内活性

ABX464属于一类具有独特属性的抗HIV新分子。在人源化小鼠中，ABX464展现出长期效果，并能中和感染免疫细胞（包括储藏库）中HIV-1前病毒基因组的表达，因此被视为HIV功能性治愈的候选化合物[1]。

溶解度

DMSO:100 mg/mL (295.24 mM)

参考文献

1.Campos N, et al. Long lasting control of viral rebound with a new drug ABX464 targeting Rev-mediated viral RNA biogenesis. Retrovirology. 2015 Apr 9;12:30.
2.Didier S , Regine R , Noel B P , et al. Pharmacokinetics and tolerability of ABX464, a novel first-in-class compound to treat HIV infection, in healthy HIV-uninfected subjects[J]. Journal of Antimicrobial Chemotherapy(3):3.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2