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Dasabuvir

CAS号

1132935-63-7

分子式

C26H27N3O5S

主要靶点

HCV Protease

仅限科研使用

Cat No : CM04368

Print datasheet

Synonyms

ABT 333|ABT333|ABT-333|genotype|Hepatitis C virus|HCVProtease|HCV polymerase|HCV Protease|HCV|HCV genotype 1 infections|inhibit|DNA/RNA Synthesis|Dasabuvir|RNA|NS5B polymerase|Inhibitor|达塞布韦

验证数据展示

  • CAS No.: 1132935-63-7

    Dasabuvir
    CAS#: 1132935-63-7

产品信息

CAS号 1132935-63-7
分子式 C26H27N3O5S
主要靶点 HCV Protease
主要通路 蛋白酶体|微生物学
分子量 493.57
纯度 99.62%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 ABT 333|ABT333|ABT-333|genotype|Hepatitis C virus|HCVProtease|HCV polymerase|HCV Protease|HCV|HCV genotype 1 infections|inhibit|DNA/RNA Synthesis|Dasabuvir|RNA|NS5B polymerase|Inhibitor|达塞布韦

靶点活性

GnRH:0.33 nM

体外活性

ABT-333 (Dasabuvir) is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases. ABT-333 (Dasabuvir) inhibits the polymerase enzymatic activity of genotype 1 laboratory strain enzymes (H77, BK, N, and Con1 strains), as well as enzymes produced from polymerase genes from HCV genotype 1-infected subjects, with IC50s between 2.2 and 10.7 nM. ABT-333 inhibits replication of HCV subgenomic replicons in cell culture assays, with EC50 values of 7.7 and 1.8 nM against genotype 1a (H77) and 1b (Con1), respectively. In the presence of 40% human plasma, there is a 12- to 13-fold decrease in inhibitory potency, yielding EC50s of 99 and 21 nM for HCV genotype 1a (H77) and 1b (Con1) replicons, respectively[1].

溶解度

DMSO:60 mg/mL (121.56 mM)

参考文献

1.Kati W, et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2015 Mar;59(3):1505-11.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2