MRP2 Polyclonal antibody
MRP2 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
ELISA
Conjugate
Unconjugated
验证数据展示
产品信息
18702-1-AP targets MRP2 in ELISA applications and shows reactivity with human samples.
| Tested Applications | ELISA |
| Tested Reactivity | human |
| Immunogen | Peptide 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
| Synonyms | ABC30, ABCC2, CMOAT, CMOAT1, cMRP, DJS, KIAA1010, MRP2 |
| Calculated Molecular Weight | 174 kDa |
| GenBank Accession Number | BC136419 |
| Gene Symbol | ABCC2 |
| Gene ID (NCBI) | 1244 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q92887 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ABCC2, also named as CMOAT, CMOAT1, CMRP and MRP2, is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABCC2 is a member of the MRP subfamily which is involved in multi-drug resistance. It is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. The substrates of ABCC2 include anticancer drugs such as vinblastine; therefore, it appears to contribute to drug resistance in mammalian cells. Several different mutations have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.