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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 20703-1-AP (same clone as 20703-1-PBS)

    WB analysis using 20703-1-AP (same clone as 20703-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20703-1-AP (ABCB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20703-1-PBS in a different storage buffer formulation.

ABCB5 Polyclonal antibody, PBS Only

ABCB5 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 20703-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

P-glycoprotein ABCB5, EC:7.6.2.2, ATP-binding cassette sub-family B member 5, ABCB5beta, ABCB5alpha

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

20703-1-PBS targets ABCB5 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 ATP-binding cassette, sub-family B (MDR/TAP), member 5
别名 P-glycoprotein ABCB5, EC:7.6.2.2, ATP-binding cassette sub-family B member 5, ABCB5beta, ABCB5alpha
计算分子量 90 kDa
观测分子量 90-110 kDa
GenBank蛋白编号NM_178559
基因名称 ABCB5
Gene ID (NCBI) 340273
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ2M3G0
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ABCB5 is an 812 amino acid multi-pass membrane protein and belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins (PMID: 15760339). ABCB5 is an Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells(PMID: 15899824, 15205344). ABCB5 acts as a marker of stem-like cells (CSC) in several malignancies and is responsible for the resistance to doxorubicin of a subset of malignant melanomas (PubMed:24934811, 15760339). Alternate splicing results in multiple transcript variants.