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AA26-9

AA26-9 是广谱丝氨酸水解酶的高效抑制剂。它的靶点包括丝氨酸肽酶、酰胺酶、脂肪酶、酯酶和硫酯酶。在永生化 T 细胞系，检测到它对 40+ 丝氨酸水解酶中的 1/3 有抑制作用。

CAS号

1312782-34-5

分子式

C7H10N4O

主要靶点

Phospholipase|Serine Protease

仅限科研使用

Cat No : CM04671

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Synonyms

验证数据展示

  • CAS No.: 1312782-34-5

    AA26-9
    CAS#: 1312782-34-5

产品信息

AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.

CAS号 1312782-34-5
分子式 C7H10N4O
主要靶点 Phospholipase|Serine Protease
主要通路 蛋白酶体|代谢
分子量 166.18
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体外活性

AA26-9 inhibits enzymes originated from diverse functional subclasses of serine hydrolases, including peptidases (APEH, CTSA, PRCP), thioesterases (LYPLA1/2), lipases/phospholipases (AADACL1, ESD, ABHD6, PAFAH2, FAAH, LYPLA3), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells.

溶解度

DMSO:55 mg/mL (330.96 mM)

细胞实验

AA26-9 is prepared in DMSO. Cells are cultured with 20 μM inhibitor AA26-9 or DMSO as a control for 4 h, lysed, separated into soluble and analyzed by competitive gel-based ABPP[1].

参考文献

1.Adibekian A, et al. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nat Chem Biol. 2011 May 15;7(7):469-78.

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