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AA26-9

CAS号

1312782-34-5

分子式

C7H10N4O

主要靶点

Phospholipase|Serine Protease

仅限科研使用

Cat No : CM04671

Print datasheet

Synonyms

peptidases|Phospholipase|Inhibitor|inhibit|lipases|serine|Serine Protease|serine hydrolase|SerineProtease|thioesterases|cell|amidases|AA26 9|AA269|AA-26-9|AA26-9|esterases

验证数据展示

  • CAS No.: 1312782-34-5

    AA26-9
    CAS#: 1312782-34-5

产品信息

CAS号 1312782-34-5
分子式 C7H10N4O
主要靶点 Phospholipase|Serine Protease
主要通路 蛋白酶体|代谢
分子量 166.18
纯度 100%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 peptidases|Phospholipase|Inhibitor|inhibit|lipases|serine|Serine Protease|serine hydrolase|SerineProtease|thioesterases|cell|amidases|AA26 9|AA269|AA-26-9|AA26-9|esterases

体外活性

AA26-9抑制T细胞中发现的40多种丝氨酸水解酶中的1/3，这些酶来自丝氨酸水解酶的不同功能亚类，包括肽酶（APEH、CTSA、PRCP）、硫酯酶（LYPLA1/2）、脂肪酶/磷脂酶（AADACL1、ESD、ABHD6、PAFAH2、FAAH、LYPLA3）以及尚未明确特性的酶（ABHD11、ABHD13、BAT5）。

溶解度

DMSO:55 mg/mL (330.96 mM)

细胞实验

AA26-9 is prepared in DMSO. Cells are cultured with 20 μM inhibitor AA26-9 or DMSO as a control for 4 h, lysed, separated into soluble and analyzed by competitive gel-based ABPP[1].

参考文献

1.Adibekian A, et al. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nat Chem Biol. 2011 May 15;7(7):469-78.

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The dilution calculator equation

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