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A-205804

CAS号

251992-66-2

分子式

C15H12N2OS2

主要靶点

Integrin

仅限科研使用

Cat No : CM04770

Print datasheet

Synonyms

Inhibitor|inhibit|Integrin|molecules|ICAM-1|E-selectin|A 205804|A205804|A-205804|Adhesion

验证数据展示

  • CAS No.: 251992-66-2

    A-205804
    CAS#: 251992-66-2

产品信息

CAS号 251992-66-2
分子式 C15H12N2OS2
主要靶点 Integrin
主要通路 细胞骨架
分子量 300.4
纯度 98.52%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|inhibit|Integrin|molecules|ICAM-1|E-selectin|A 205804|A205804|A-205804|Adhesion

靶点活性

ICAM1:25 nM|Eselectin:20 nM

体内活性

在人内皮细胞中,A-205804选择性抑制ICAM-1(IC50 = 10 nM)和E-selectin (IC50 = 20 nM)。

溶解度

Ethanol:3 mg/mL (9.99 mM);DMSO:30 mg/mL (99.87 mM)

参考文献

1.Zhu GD, et al. J Med Chem, 2001, 44(21), 3469-3487.
2.Stewart AO, J Med Chem, 2001, 44(6), 988-1002.
3.Liu Y, Zhao X, Ding J, et al. Evidence of Accumulated Endothelial Progenitor Cells in the Lungs of Rats with Pulmonary Arterial Hypertension by 89Zr-oxine PET Imaging. Molecular Therapy-Methods & Clinical Development. 2020.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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