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A-205804

A-205804 是一种选择性口服有效的先导抑制剂，抑制 E-selectin 和 ICAM-1表达，IC50分别为 20 nM 和 25 nM，可用于慢性炎症疾病的研究。

CAS号

251992-66-2

分子式

C15H12N2OS2

主要靶点

Integrin

仅限科研使用

Cat No : CM04770

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Synonyms

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  • CAS No.: 251992-66-2

    A-205804
    CAS#: 251992-66-2

产品信息

A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.

CAS号 251992-66-2
分子式 C15H12N2OS2
主要靶点 Integrin
主要通路 细胞骨架
分子量 300.41
纯度 98.52%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

E-selectin:20 nM|ICAM-1:25 nM

体内活性

在人内皮细胞中,A-205804选择性抑制ICAM-1(IC50 = 10 nM)和E-selectin (IC50 = 20 nM)。

溶解度

DMSO:30 mg/mL (100 mM),Ethanol:3 mg/mL (10 mM)

参考文献

1.Zhu GD, et al. J Med Chem, 2001, 44(21), 3469-3487.
2.Stewart AO, J Med Chem, 2001, 44(6), 988-1002.
3.Liu Y, Zhao X, Ding J, et al. Evidence of Accumulated Endothelial Progenitor Cells in the Lungs of Rats with Pulmonary Arterial Hypertension by 89Zr-oxine PET Imaging. Molecular Therapy-Methods & Clinical Development. 2020.

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