• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

9-ING-41

CAS号

1034895-42-5

分子式

C22H13FN2O5

主要靶点

Apoptosis|GSK-3|Autophagy

仅限科研使用

Cat No : CM04319

Print datasheet

Synonyms

Inhibitor|9ING41|9-ING-41|9 ING 41|anticancer|arrest|Apoptosis|activity|Autophagy|cell|cycle|inhibit|GSK-3β|GSK-3|GSK3|Glycogen synthase kinase 3|Glycogen synthase kinase-3

验证数据展示

  • CAS No.: 1034895-42-5

    9-ING-41
    CAS#: 1034895-42-5

产品信息

CAS号 1034895-42-5
分子式 C22H13FN2O5
主要靶点 Apoptosis|GSK-3|Autophagy
主要通路 干细胞|PI3K/Akt/mTOR 信号通路|凋亡|自噬
分子量 404.35
纯度 97.64%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|9ING41|9-ING-41|9 ING 41|anticancer|arrest|Apoptosis|activity|Autophagy|cell|cycle|inhibit|GSK-3β|GSK-3|GSK3|Glycogen synthase kinase 3|Glycogen synthase kinase-3

靶点活性

GSK-3β:0.71 μM (IC50)

体内活性

在小鼠MCL模型中，9-ING-41（40 mg/kg/隔日；共17天）表现出单药抗肿瘤活性[2]。

体外活性

9-ING-41（2, 4 μM；48小时）能减少神经母细胞瘤细胞的活性并诱导凋亡[2]。9-ING-41（1, 2 μM；24小时）对淋巴瘤细胞具有强大的细胞周期阻断作用[2]。9-ING-41（0.1-1 μM）通过抑制GSK-3，从而降低NF-κB靶点XIAP的表达，并通过PARP切割（一种凋亡标志）显著诱导神经母细胞瘤细胞的凋亡[1]。9-ING-41（0.5, 1.0, 1.5, 2.0 μM）能够抑制所有TCL和MCL系列的增殖率，浓度低至1.0 mM即可见效[2]。

溶解度

DMSO:97 mg/mL (239.89 mM)

参考文献

1.Ugolkov AV, et al. 9-ING-41, a small-molecule glycogen synthase kinase-3 inhibitor, is active in neuroblastoma. Anticancer Drugs. 2018 Sep;29(8):717-724.
2.Wu X, et al. Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma. Blood. 2019 Jul 25;134(4):363-373.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2