• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

740 Y-P

CAS号

1236188-16-1

分子式

C141H222N43O39PS3

主要靶点

Autophagy|PI3K

仅限科研使用

Cat No : CM05933

Print datasheet

Synonyms

Autophagy|alzheimer's disease|aortic|740 YP|740 Y-P|740 Y P|740YPDGFR|PI3K|PDGFR 740Y-P|p85 binding|VSMC|SH2|thoracic

验证数据展示

  • CAS No.: 1236188-16-1

    740 Y-P
    CAS#: 1236188-16-1

产品信息

CAS号 1236188-16-1
分子式 C141H222N43O39PS3
主要靶点 Autophagy|PI3K
主要通路 PI3K/Akt/mTOR 信号通路|自噬
分子量 3270.7
纯度 99.87%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Autophagy|alzheimer's disease|aortic|740 YP|740 Y-P|740 Y P|740YPDGFR|PI3K|PDGFR 740Y-P|p85 binding|VSMC|SH2|thoracic

体外活性

740 Y-P是一种合成的生物素化肽。在最低浓度测试(1 mg/mL)时，740 Y-P可刺激细胞增生。该肽在有无血清(0.5%)的情况下均可刺激细胞增生，其中在有血清的情况下，50 mg/mL时观察到最大反应。740 Y-P刺激细胞增生的能力高度特异，这并非细胞渗透SH2结合域肽的一般特性[1]。740 Y-P在通过已建立的PI 3-激酶-Akt生存级联促进神经细胞存活方面，与生长因子(FGF2)一样有效。PDGFR740Y-P肽刺激神经细胞存活的效果是剂量依赖的，并且不需要胰岛素[2]。

溶解度

DMSO:50 mg/mL (15.29 mM);H2O:5.5 mg/mL (1.68 mM)

参考文献

1.Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem Biophys Res Commun. 1998 Oct 9;251(1):148-52.
2.Williams EJ, Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol Cell Neurosci. 1999 Apr;13(4):272-80.
3.Zhao Y, Guo W, Gu X, et al. Repression of deoxynivalenol-triggered cytotoxicity and apoptosis by mannan/β-glucans from yeast cell wall: Involvement of autophagy and PI3K-AKT-mTOR signaling pathway[J]. International Journal of Biological Macromolecules. 2020, 164: 1413-1421.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2