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7-FluorotryptaMine HCl

7-FluorotryptaMine HCl 是一种有效的芳香单胺 GPRC5A 激动剂，可诱导 GPRC5A 介导的 β-arrestin 募集。7-FluorotryptaMine HCl 可用于研究与免疫和癌症相关的信号通路。

CAS号

159730-09-3

分子式

C10H12ClFN2

主要靶点

GPR

仅限科研使用

Cat No : CM11144

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Synonyms

验证数据展示

  • CAS No.: 159730-09-3

    7-FluorotryptaMine HCl
    CAS#: 159730-09-3

产品信息

7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer.

CAS号 159730-09-3
分子式 C10H12ClFN2
主要靶点 GPR
主要通路 内分泌与激素|G蛋白偶联受体
分子量 214.67
纯度 98.06%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
别名

体外活性

In the PRESTO-Tango assay, 7-FluorotryptaMine HCl (100 μM) hydrochloride induces GPRC5A recruitment of β-arrestin.[1] Co-treatment with 7-FluorotryptaMine HCl (50 μM, 8 h) and TNFα downregulates TNFα-induced genes (e.g., IL41A, CXCL10, CSF2) in WT and GPRC5A-KO cells [1]. 7-FluorotryptaMine HCl (0-100 μM, 16 h) is not toxic to mammalian cells (HTLA, HT-29 cells).[1]

溶解度

DMSO:21.47 mg/mL (100 mM)

参考文献

1.Zhao X, et al. Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A. Nat Chem Biol. 2023 Oct;19(10):1205-1214.

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