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7-Chlorokynurenic acid

CAS号

18000-24-3

分子式

C10H6ClNO3

主要靶点

GluR|NMDAR

仅限科研使用

Cat No : CM05292

Print datasheet

Synonyms

reuptake of glutamate|NMDA receptor|7-氯犬尿酸|7-CKA|7-Chlorokynurenic acid|7-chloro-4-hydroxy-2-carboxyquinoline|Glutamate receptor|Glycine B coagonist site of NMDA receptor

验证数据展示

  • CAS No.: 18000-24-3

    7-Chlorokynurenic acid
    CAS#: 18000-24-3

产品信息

CAS号 18000-24-3
分子式 C10H6ClNO3
主要靶点 GluR|NMDAR
主要通路 神经科学|神经科学
分子量 223.61
纯度 99.72%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 reuptake of glutamate|NMDA receptor|7-氯犬尿酸|7-CKA|7-Chlorokynurenic acid|7-chloro-4-hydroxy-2-carboxyquinoline|Glutamate receptor|Glycine B coagonist site of NMDA receptor

靶点活性

Glycine B coagonist site of NMDA receptor:0.56 μM(ki)|Reuptake of glutamate:（ki）0.59 μM

体内活性

在雄性Sprague-Dawley大鼠中，7-Chlorokynurenic acid（10 nM）延缓了癫痫反应的电脑图及运动（每日17.7次刺激）组分的发展[3]。

溶解度

DMSO:15 mg/mL (67.1 mM)

参考文献

1.Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50.
2.Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196.
3.Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118(1):29-32.

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