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7,4'-Dihydroxyflavone

CAS号

2196-14-7

分子式

C15H10O4

主要靶点

COX|CCR|HDAC|NOD|NF-κB

仅限科研使用

Cat No : CM11552

Print datasheet

Synonyms

Inhibitor|Nuclear factor-kappaB|Nuclear factor-κB|NOD1|NF-kB|NFκB|NF-κB|NFkB|COX|inhibit|HDAC2|7,4'-二羟基黄酮|7,4'Dihydroxyflavone|7,4'-Dihydroxyflavone|7,4' Dihydroxyflavone|4',7-Dihydroxyflavone|CC chemokine receptor|CCR

验证数据展示

  • CAS No.: 2196-14-7

    7,4'-Dihydroxyflavone
    CAS#: 2196-14-7

产品信息

CAS号 2196-14-7
分子式 C15H10O4
主要靶点 COX|CCR|HDAC|NOD|NF-κB
主要通路 神经科学|免疫与炎症|DNA 损伤和修复|表观遗传|NF-κB 信号通路|免疫与炎症|微生物学|G 蛋白偶联受体|免疫与炎症|NF-κB 信号通路
分子量 254.24
纯度 99.6%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|Nuclear factor-kappaB|Nuclear factor-κB|NOD1|NF-kB|NFκB|NF-κB|NFkB|COX|inhibit|HDAC2|7,4'-二羟基黄酮|7,4'Dihydroxyflavone|7,4'-Dihydroxyflavone|7,4' Dihydroxyflavone|4',7-Dihydroxyflavone|CC chemokine receptor|CCR

靶点活性

NCI-H292 cells:1.4 μM (NCI-H292 human airway epithelial cell) (IC50)

体外活性

三天龄苜蓿幼苗的根分泌物被纯化后，使用nodABC-lacZ融合体在R. meliloti中进行了生物活性测定。通过光谱分析（紫外/可见光、质子核磁共振、及质谱分析）以及与标准样品的比对，确定了主要诱导因子的身份。主要诱导因子被鉴定为7,4'-Dihydroxyflavone、4'-7-二羟基黄烷酮、和4,4'-二羟基-2'-甲氧基查尔酮，它们分别以54、22和20 picomole.plant(-1).day(-1)的速率从幼苗根部释放。在这些根分泌物中未发现木犀草素。

溶解度

DMSO:250 mg/mL (983.32 mM)

参考文献

1.A Chalcone and Two Related Flavonoids Released from Alfalfa Roots Induce nod Genes of Rhizobium meliloti.Plant Physiol., 1989, 91(3):842-7.

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