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6-APA

6-APA is the core moiety of penicillins.

CAS号

551-16-6

分子式

C8H12N2O3S

主要靶点

Antibacterial

仅限科研使用

Cat No : CM00750

Print datasheet

Synonyms

6-Aminopenicillanic Acid

验证数据展示

  • CAS No.: 551-16-6

    6-APA
    CAS#: 551-16-6

  • 6-APA<br/>CAS#: 551-16-6

    6-APA
    CAS#: 551-16-6

产品信息

6-APA (6-aminopenicillanic acid), is used to prepare raw materials for semi synthetic penicillin. In the fermentation broth of P. chrysogenum it is necessary to distinguish between the primary 6-APA which is a product of the biosynthesis via L-cystine/D-valine and the secondary 6-APA which originates from isopenicillin N[2]. The overall yield of 6-APA crystals obtained after enzymatic conversion of penicillin G ranged between 37-55 and 47-68% in foreign and local strains, respectively[3]. Moreover, 6-APA slightly reduced the exogenous acetylcholine-induced contractile response and this effect was a little weaker than it is on the intramural electrical stimulation-induced contractile response[4]. Combinations of mecillinam and 6-APA with ampicillin acted synergistically against the gram-negative bacilli[5].

CAS号 551-16-6
分子式 C8H12N2O3S
主要靶点 Antibacterial
主要通路 Anti-infection
分子量 216.2575
MDL NO MFCD00005176
Pubchem ID 11082
纯度 98%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
粉末 -20°C 3年
液体 -80°C 1年
运输条件 Shipped in cold pack
别名 6-Aminopenicillanic Acid

靶点

TargetActivity

溶解度

DMSO1 mg/mL
WaterInsoluble
EthanolInsoluble

参考文献

1Batchelor FR, Doyle FP, et al. Synthesis of penicillin: 6-aminopenicillanic acid in penicillin fermentations. Nature. 1959 Jan 24;183(4656):257-8.
2Bosnic P, Gelineo A, Gajic B. Biogenez 6-aminopenitsillanovo? kisloty (6-APK) i penitsillina u Penicillium chrysogenum; éffekt biokatalizatora khrizina [Biogenesis of 6-aminopenicillanic acid (6-APA) and penicillin in Penicillium chrysogenum: effect of the biocatalyst chrysin]. Antibiot Khimioter. 1994;39(9-10):6–11
3Arshad R, Farooq S, Ali SS. 6-aminopenicillanic acid production by intact cells of E. coli containing penicillin G acylase (PGA). Pak J Biol Sci. 2007;10(18):3190–3194
4Yoshida M, Koeda T. Effects of aminobenzyl penicillin (AB-PC), methylchlorophenyl isoxazolyl penicillin (MCI-PC) and 6-aminopenicillanic acid (6-APA) on the contractile response of guinea-pig urinary bladder. Nihon Heikatsukin Gakkai Zasshi. 1984;20(1):1–12
5Lorian V, Atkinson B. Comparison of the effects of mecillinam and 6-aminopenicillanic acid on Proteus mirabilis, Escherichia coli, and Staphylococcus aureus. Antimicrob Agents Chemother. 1977;11(3):541–552

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2