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5-Ethynyl-2'-deoxyuridine

CAS号

61135-33-9

分子式

C11H12N2O5

主要靶点

Others|PROTAC Linker

仅限科研使用

Cat No : CM01973

Print datasheet

Synonyms

inhibit|Alkyl-Chain|5-Ethynyl-2'-deoxyuridine|5Ethynyl2'deoxyuridine|5 Ethynyl 2' deoxyuridine|5-乙炔基-2-脱氧尿苷|Inhibitor|PROTAC Linker|PROTACLinker|PROTAC Linkers

验证数据展示

  • CAS No.: 61135-33-9

    5-Ethynyl-2'-deoxyuridine
    CAS#: 61135-33-9

产品信息

CAS号 61135-33-9
分子式 C11H12N2O5
主要靶点 Others|PROTAC Linker
主要通路 PROTAC
分子量 252.22
纯度 100%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 inhibit|Alkyl-Chain|5-Ethynyl-2'-deoxyuridine|5Ethynyl2'deoxyuridine|5 Ethynyl 2' deoxyuridine|5-乙炔基-2-脱氧尿苷|Inhibitor|PROTAC Linker|PROTACLinker|PROTAC Linkers

体外活性

PROTACs通过连接两个不同的配体（一个为E3泛素连接酶的配体，另一个为靶蛋白的配体）实现其功能，利用细胞内的泛素-蛋白酶体系统有选择性地降解靶蛋白[1]。如5-溴-2'-脱氧尿苷（BrdU）及EdU在DNA活跃合成期被嵌入DNA中，随后可通过使用荧光偶氮探针及铜催化的1,3-偶极环加成反应进行检测。包括EdU在内的改性核苷类在长时间添加至细胞中可能具有细胞毒性[2]。5-Ethynyl-2'-deoxyuridine（EdU）染色是一种快速、敏感且可复制的方法，用于研究中枢神经系统中的细胞增殖[3]。

溶解度

DMSO:120 mg/mL (475.77 mM);H2O:8 mg/mL (31.72 mM)

参考文献

1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
2.Cavanagh B L , Walker T , Norazit A , et al. Thymidine Analogues for Tracking DNA Synthesis[J]. Molecules, 2011, 16(9):7980-7993.
3.Zeng C , Pan F , Jones L A , et al. Evaluation of 5-ethynyl-2'-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system.[J]. Brain Research, 2010, 1319(none):21-32.

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